机械介入取栓术联合阿替普酶静脉溶栓对急性脑梗死神经功能及TIMI分级的影响  

Effect of Mechanical Interventional Thrombectomy Combined with Alteplase Intravenous Thrombolysis on Neurological Function and TIMI Grading in Patients with Acute Cerebral Infarction

作　　者：高营礼 贾永林 张保华 GAO Ying-li;JIA Yong-lin;ZHANG Bao-hua(No.2 Ward of Neurology Department,Kaifeng Central Hospital,Kaifeng 475000,Henan Province,China)

机构地区：[1]开封市中心医院神经内科二病区,河南开封475000

出　　处：《罕少疾病杂志》2024年第7期10-12,共3页Journal of Rare and Uncommon Diseases

基　　金：2022年度开封市科技发展计划项目(2203060)。

摘　　要：目的探讨机械介入取栓术联合阿替普酶静脉溶栓对急性脑梗死患者神经功能及TIMI分级的影响。方法选取2020年1月-2023年2月在本院就诊的急性脑梗死患者42例,将单一应用阿替普酶静脉溶栓治疗的患者21例纳入对照组,将机械介入取栓术联合阿替普酶静脉溶栓治疗的患者21例纳入观察组。统计两组治疗有效率、血清PON-1、hs-CRP、Lp-PLA2、NSE水平、mRs评分、BI评分、NIHSS评分、不良反应情况、TIMI分级。结果观察组治疗有效率95.24%高于对照组(P<0.05);观察组血清PON-1水平高于对照组(P<0.05),hs-CRP、Lp-PLA2、NSE水平低于对照组(P<0.05);观察组mRs评分、NIHSS评分低于对照组(P<0.05),BI评分高于对照组(P<0.05);两组不良反应情况比较,P>0.05;观察组TIMI分级优于对照组(P<0.05)。结论机械介入取栓术联合阿替普酶静脉溶栓有利于改善神经功能、TIMI分级,提高患者日常生活能力,安全性良好,临床疗效显著。Objective To investigate the effects of mechanical interventional thrombectomy combined with alteplase intravenous thrombolysis on neurological function and TIMI grading in patients with acute cerebral infarction.Methods A total of 42 patients with acute cerebral infarction admitted to our hospital from January 2020 to February 2023 were selected,21 patients receiving intravenous thrombolysis therapy with alteplase alone were included in the control group,and 21 patients receiving intravenous thrombolysis therapy with mechanical interventional thrombolysis combined with alteplase were included in the observation group.The treatment effective rate,serum PON-1,hs-CRP,Lp-PLA2,NSE levels,mRs Score,BI score,NIHSS score,adverse reactions and TIMI score of the two groups were analyzed.Results The effective rate of observation group was 95.24%higher than that of control group(P<0.05).The serum PON-1 level in observation group was higher than that in control group(P<0.05),the levels of hs-CRP,Lp-PLA2 and NSE were lower than that in control group(P<0.05).mRs Scores and NIHSS scores in observation group were lower than those in control group(P<0.05),BI scores were higher than those in control group(P<0.05);The adverse reactions of the two groups were compared,P>0.05;The TIMI grade of observation group was better than that of control group(P<0.05).Conclusions Mechanical interventional thrombectomy combined with alteplase intravenous thrombolysis is beneficial to improve neurological function,TIMI grading,and daily living ability of patients,with good safety and significant clinical efficacy.

关 键 词：机械介入取栓术 阿替普酶 静脉溶栓 急性脑梗死 神经功能 TIMI分级 

分 类 号：R743[医药卫生—神经病学与精神病学]