早期阿尔茨海默病诊疗路径的精神科实践指导  

Practical guidance on the pathway for diagnosis and treatment of early Alzheimer′s disease

作　　者：中国老年医学学会精神医学与心理健康分会 王华丽[2] 于欣[3] 王刚[4] 刘莎[5] Chinese Society of Geriatric Psychiatry;Wang Huali;Yu Xin(不详;Dementia Care and Research Center,Peking University Sixth Hospital,Beijing 100191,China;Beijing Key Laboratory for Translational Research of Diagnosis and Treatment for Dementia,Peking university Sixth Hospital,Being 100191,China)

机构地区：[1]不详 [2]北京大学第六医院记忆障碍诊疗与研究中心,北京100191 [3]北京大学第六医院痴呆诊治转化医学研究北京市重点实验室,北京100191 [4]上海交通大学医学院附属仁济医院神经内科 [5]山西医科大学第一医院精神卫生科

出　　处：《中华精神科杂志》2024年第7期407-413,共7页Chinese Journal of Psychiatry

基　　金：科技创新2030-“脑科学与类脑研究”重大项目(2021ZD0201805)。

摘　　要：阿尔茨海默病(Alzheimer′s disease,AD)起病隐袭,渐进发展。早期AD(包括AD源性轻度认知损害和轻度痴呆)的诊断和治疗对改善疾病预后、减轻照护负担有重要意义。早期AD患者不仅存在认知缺陷,还可能合并轻度精神行为改变。本实践指导意见由中国老年医学学会精神医学和心理健康分会组织国内专家编写,阐述了早期AD的诊断思路和关键步骤、制定治疗策略应关注的事项以及疗效与安全性监测等,以期指导精神科医生的临床实践,提高早期AD的正确诊断率,并规范使用疾病修饰治疗。Alzheimer′s disease(AD)is an insidious and progressive degenerative neuropsychiatric disorder.The diagnosis and treatment of early AD,including mild cognitive impairment and dementia due to AD,are significant for improving disease outcomes and reducing caregiver burden.Individuals with early AD present cognitive deficits as well as mild psychological and behavioral changes.The present practical guidance is developed by national experts convened by the Chinese Society of Geriatric Psychiatry.It focuses on the clinical topics related to the diagnosis and treatment of early AD,including the diagnostic strategy,key approaches for making a diagnosis,the considerations for initiating disease-modifying therapies(DMT),and monitoring the effectiveness and safety of DMT.The practical guidance is anticipated to facilitate the diagnosis and appropriate medication with disease-modifying therapies for early AD.

关 键 词：阿尔茨海默病 早期诊断 疾病修饰治疗 

分 类 号：R749.16[医药卫生—神经病学与精神病学]