吸烟成瘾及超重间交互作用与脑灰质体积的相关性分析  

Analysis of the interactive effects between smoking addiction and overweight on brain gray matter volume

作　　者：张孟哲 牛晓玉 党婧涵 孙洁萍 汪卫建 程敬亮[1] 张勇[1] Zhang Mengzhe;Niu Xiaoyu;Dang Jinghan;Sun Jieping;Wang Weijian;Cheng Jingiang;Zhang Yong(Department of MRI,First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学第一附属医院磁共振科,郑州450052

出　　处：《中华精神科杂志》2024年第7期433-439,共7页Chinese Journal of Psychiatry

基　　金：河南省重点研发与推广专项(科技攻关)(212102310712)。

摘　　要：目的探讨吸烟成瘾与超重之间的交互作用与脑灰质体积的相关性。方法回顾性分析2019年1月至2021年12月通过微信等网络平台招募的99名受试者的相关临床资料及磁共振成像数据,包括以下4组:超重吸烟成瘾组(n=24);正常体重吸烟成瘾组(n=28);超重非吸烟组(n=19);正常体重非吸烟组(n=28)。所有受试者均行3.0T MRI检查。采用基于体素的形态学测量(voxel-based morphometry,VBM)的方法比较4组间的灰质体积(gray matter volume,GMV)的差异。采用双因素方差分析,将年龄、受教育年限和头部运动作为协变量,分析吸烟成瘾与超重对于大脑结构的交互作用、吸烟成瘾的主效应及超重的主效应,并将其与临床资料做相关性分析。结果吸烟成瘾和超重在大脑左侧背外侧前额叶皮质(dorsolateral prefrontal cortex,DLPFC)存在显著的交互作用(GRF校正,体素水平P<0.001,团块水平P<0.05)。相关分析显示,体重指数与左侧DLPFC GMV存在二次效应(β=-3.846,t=-2.134,P=0.036)。此外,吸烟成瘾主效应主要表现在大脑双侧眶额叶皮质(orbitofrontal cortex,OFC)(GRF校正,体素水平P<0.001,团块水平P<0.05)。相关分析发现左侧OFC GMV与尼古丁依赖量表评分呈负相关(r=-0.391,P=0.006),右侧OFC GMV与吸烟指数呈负相关(r=-0.335,P=0.019)。在上述阈值水平未发现有统计学意义的超重主效应。结论吸烟成瘾与超重在左侧DLPFC GMV存在拮抗作用。ObjectiveTo investigate the correlation between brain gray matter volume(GMV)and interactive effects of smoking addiction and overweight.MethodsWe retrospectively analyzed the clinical data and resting-state functional magnetic resonance imaging data of 99 subjects recruited from January 2019 to December 2021 through online platforms such as WeChat,including the following four groups:overweight smoking addiction group(n=24),normal-weight smoking addiction group(n=28),overweight non-smoking group(n=19),and normal-weight non-smoking group(n=28).All subjects underwent 3.0T MRI.We used voxel-based morphometry(VBM)to compare gray matter volume(GMV)among the four groups.A two-way analysis of variance was conducted with age,years of education,and head motion as covariates to explore the interaction effects between smoking addiction and weight status on GMV,the main effect of smoking addiction and main effect of overweight,which were then correlated with clinical data.ResultsSignificant interactive effects of smoking addiction and overweight were observed in the left dorsolateral prefrontal cortex(DLPFC)(GRF corrected,voxel-level P<0.001,cluster-level P<0.05).Correlation analysis showed a quadratic effect between body mass index and left DLPFC GMV(β=-3.846,t=-2.134,P=0.036).Additionally,the main effect of smoking addiction was primarily manifested in the bilateral orbitofrontal cortex(OFC)(GRF corrected,P voxel<0.001,P cluster<0.05).Left OFC GMV was negatively associated with the FTND(Fagerstrom Test of Nicotine Dependence)scores(r=-0.391,P=0.006).And right OFC GMV was negatively correlated with the smoking index(r=-0.335,P=0.019).No statistically significant main effect of overweight was found at the aforementioned threshold.ConclusionSmoking addiction and overweight have antagonistic effects on left DLPFC GMV.

关 键 词：行为 成瘾 吸烟 超重 交互 灰质体积 基于体素形态学测量 

分 类 号：R749.6[医药卫生—神经病学与精神病学]