运动干预对睡眠障碍脑异常激活的补偿作用:一项脑成像元分析  

Compensatory effects of exercise on abnormal brain activation in sleep disorders:an activation likelihood estimation meta-analysis

作　　者：李婉婷 段立晖 吴佳雯 杨思雨[1] 孙淮庆 吴婷[1] LI Wanting;DUAN Lihui;WU Jiawen(Department of Neurology,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China)

机构地区：[1]南京医科大学第一附属医院神经内科,210029

出　　处：《临床神经病学杂志》2024年第3期166-173,共8页Journal of Clinical Neurology

基　　金：国家自然科学基金资助项目(81772454,81971237);江苏省科技厅社会发展项目(BE2017734);江苏省重点研发计划重点项目(BE2023023-2)。

摘　　要：目的探讨运动对睡眠障碍造成的脑激活异常的补偿作用。方法通过激活似然比估计(ALE)对睡眠障碍所致脑激活异常和运动相关脑激活变化进行脑成像元分析。结果共纳入119项研究。在睡眠障碍相关的异常脑区和运动干预后的脑区中,两侧半球的额叶、海马体、颞叶上中回和丘脑部分区域共同激活。结论运动可能对缓解睡眠障碍引起的脑激活异常具有重要补偿作用。Objective To explore the compensatory effect of exercise on brain activation abnormalities caused by sleep disorders.Methods Brain imaging meta-analysis was conducted using activation likelihood estimation(ALE)to investigate brain activation abnormalities caused by sleep disorders and changes in brain activation related to exercise.Results A total of 119 studies were included,and it was found that there was widespread activation in the bilateral frontal areas,hippocampus,superior and middle temporal gyri,and some regions of the thalamus in abnormal brain regions related to sleep disorders and brain regions after exercise intervention.Conclusion Exercise may play an important role in alleviating brain activation abnormalities caused by sleep disorders.

关 键 词：睡眠障碍 失眠 运动 激活似然比估计 

分 类 号：R749.05[医药卫生—神经病学与精神病学]