血肿周围脑组织中G蛋白信号调节因子2表达水平与高血压脑出血患者炎症反应及短期预后的关系  

Relationship between the expression of regulators of G-protein signalling 2 in brain tissue around hematoma and inflammatory response,short-term prognosis of patients with hypertensive intracerebral hemorrhage

作　　者：姚焱鹏 曹栋栋 李利超 YAO Yanpeng;CAO Dongdong;LI Lichao(Department of Neurosurgery,Affiliated Hospital of GanSu Medical College,Pingliang 744000,China)

机构地区：[1]甘肃医学院附属医院神经外科,平凉744000

出　　处：《临床神经病学杂志》2024年第3期188-192,共5页Journal of Clinical Neurology

摘　　要：目的研究血肿周围脑组织中G蛋白信号调节因子2(RGS2)表达水平与高血压脑出血患者炎症反应及短期预后的关系。方法选择2019年5月至2022年5月接受血肿清除术的高血压脑出血患者124例作为脑出血组,取22例接受尸检的非脑出血患者作为对照组。检测脑组织中RGS2、TNF-α和IL-1β的蛋白表达水平;根据脑出血患者出院后3个月时的mRS评分,分为预后良好患者和预后不良患者;采用Pearson检验分析RGS2与TNF-α、IL-1β的相关性,采用Logistic回归分析脑出血患者短期预后的影响因素,采用ROC曲线分析RGS2、TNF-α、IL-1β对脑出血患者短期预后的预测价值。结果脑出血组血肿周围脑组织中RGS2的蛋白相对表达水平低于对照组,TNF-α、IL-1β的蛋白相对表达水平高于对照组(均P<0.05);脑出血组血肿周围脑组织中RGS2与TNF-α、IL-1β的蛋白相对表达水平呈负相关;脑出血组中预后不良患者的入院时NIHSS评分、入院即刻血糖水平、脑出血体积、血肿周围脑组织中TNF-α、IL-1β的蛋白相对表达水平均高于预后良好患者,RGS2的蛋白相对表达水平均低于预后良好患者(均P<0.05)。Logistic回归分析显示,NIHSS评分、血肿体积、TNF-α、IL-1β、RGS2的蛋白相对表达水平是脑出血组患者短期预后不良的影响因素;ROC曲线分析显示,RGS2的蛋白相对表达水平对脑出血组患者的短期预后具有预测价值。结论高血压脑出血血肿周围脑组织中RGS2表达降低与炎症反应激活、短期预后不良有关。Objective To study the relationship between the expression level of regulators of G-protein signalling 2(RGS2)in brain tissue around hematoma and inflammatory response,short-term prognosis of patients with hypertensive intracerebral hemorrhage.Methods A total of 124 patients with hypertensive intracerebral hemorrhage who underwent hematoma clearance in our hospital from May 2019 to May 2022 were selected as the cerebral hemorrhage group,22 patients with non cerebral hemorrhage who underwent autopsy were selected as the control group.The protein expression of RGS2,TNF-α,IL-1βwere detected.The mRS scores of patients with intracerebral hemorrhage at 3 months after discharge were evaluated,patients were divided into patients with good prognosis and patients with poor prognosis.Pearson test was used to analyze correlation between RGS2 and TNF-α,IL-1β.Logistic regression was used to analyze the influencing factors of the short-term prognosis of patients with cerebral hemorrhage,ROC curve was used to analyze the predictive value of RGS2,TNF-α,IL-1βfor the short-term prognosis of patients with cerebral hemorrhage.Results The relative expression level of RGS2 protein in brain tissue around hematoma of cerebral hemorrhage group was lower than that in control group,the relative expression level of TNF-α,IL-1βwere higher than those of the control group(all P<0.05).There was a negative correlation between the relative expression level of RGS2 and TNF-α,IL-1β.The NIHSS score,random blood glucose level,cerebral hemorrhage volume and the relative expression level of TNF-α,IL-1βof patients with poor prognosis in the cerebral hemorrhage group were higher than those of patients with good prognosis,and the relative expression level of RGS2 was lower than that of patients with good prognosis(all P<0.05).Logistic regression analysis showed that NIHSS score,hematoma volume and the relative expression level of RGS2,TNF-α,IL-1βwere influencing factors of the short-term prognosis of patients with cerebral hemorrhage.ROC curv

关 键 词：高血压脑出血 G蛋白信号调节因子2 炎症反应 短期预后 影响因素 预测价值 

分 类 号：R743.34[医药卫生—神经病学与精神病学]