室管膜下区IDH野生型胶质母细胞瘤的MRI表现与MGMT及Ki-67相关性分析  

Correlation analysis of MRI characteristics with MGMT and Ki-67 in IDH wild-type glioblastoma located in the subventricular zone

作　　者：邱思凡 柯志虹 林丽丹 胡雅诺 张游 许尚文[1,2] QIU Sifan;KE Zhihong;LIN Lidan;HU Yanuo;ZHANG You;XU Shangwen(Fuzong Clinical Medical College of Fujian Medical University,Fuzhou 350025,China;Department of Diagnostic Radiology,the 900th Hospital of the Joint Logistics Support Force of Chinese People’s Liberation Army,Fuzhou 350025,China;Department of Radiology,the Second People’s Hospital Affiliated to Fujian Traditional Chinese Medical University,Fuzhou 350003,China)

机构地区：[1]福建医科大学福总临床医学院,福建福州350025 [2]中国人民解放军联勤保障部队第九〇〇医院放射诊断科,福建福州350025 [3]福建中医药大学附属第二人民医院影像科,福建福州350003

出　　处：《实用放射学杂志》2024年第6期870-874,共5页Journal of Practical Radiology

基　　金：福建省科技计划项目(2023Y0066)。

摘　　要：目的探讨室管膜下区(SVZ)相关的异柠檬酸脱氢酶(IDH)野生型胶质母细胞瘤(GBM)的MRI表现及其与Ki-67表达、O^(6)-甲基鸟嘌呤DNA甲基转移酶(MGMT)启动子甲基化状态之间的相关性。方法回顾性分析经手术及病理证实的78例IDH野生型GBM患者的资料,分别从术前MRI T1WI增强序列上SVZ受累情况及术后肿瘤分子检测Ki-67表达、MGMT甲基化状态进行分组。结果SVZ受累(+)组(P<0.001)及MGMT(+)组(P=0.036)表现出了更大的肿瘤体积;各组中性别、年龄、左/右半球偏侧性分布、特定脑叶分布等方面无显著差异。组间比较结果显示Ki-67表达水平、MGMT甲基化状态与SVZ受累情况之间无显著关联。结论SVZ(+)组及MGMT(+)组表现出了更广泛的肿瘤侵袭范围。Objective To investigate the MRI characteristics of subventricular zone(SVZ)-associated isocitrate dehydrogenase(IDH)wild-type glioblastoma(GBM)and their correlations with Ki-67 expression and O^(6)-methylguanine-DNA methyltransferase(MGMT)promoter methylation status.Methods A retrospective analysis was conducted on data of 78 patients with IDH wild-type GBM who underwent surgery and received pathological confirmation.Preoperative MRI contrast-enhanced T1WI sequences were used to assess SVZ involvement,and postoperative molecular testing of tumor markers,including Ki-67 expression and MGMT methylation status,was utilized to categorize the patients accordingly.Results The SVZ involved(+)group(P<0.001)and the MGMT(+)group(P=0.036)exhibited significantly larger tumor volumes.There were no significant differences between the groups in terms of gender,age,left/right hemispheric lateralization,or specific brain lobe distribution.There was no significant association between Ki-67 expression levels,MGMT methylation status,and SVZ involvement,respectively.Conclusion The SVZ(+)group and the MGMT(+)group demonstrates a wider range of tumor invasion.

关 键 词：IDH野生型胶质母细胞瘤 室管膜下区 KI-67 MGMT启动子甲基化 

分 类 号：R739.41[医药卫生—肿瘤] R445.2[医药卫生—临床医学] R446.8