心脉通胶囊质量标准研究  

Study on Quality Standard for Xinmaitong Capsule

作　　者：王影超 刘兴鹏[1] 周青 廖敏[1] 陈凤 Wang Yingchao;Liu Xingpeng;Zhou Qing;Liao Min;Chen Feng(Guizhou institute for Food and Drug Control,Guiyang 550001,China)

机构地区：[1]贵州省食品药品检验所,贵州贵阳550001

出　　处：《广东化工》2024年第12期50-52,44,共4页Guangdong Chemical Industry

基　　金：2022年度国家药品标准制修订研究课题(2022Z024)。

摘　　要：目的:统一并提高心脉通胶囊的质量标准。方法:采用薄层色谱鉴别法(TLC)检验决明子和槐米;采用高效液相色谱法(HPLC)测定阿魏酸、葛根素的含量。结果:TLC法斑点清晰,分离度好,专属性强。阿魏酸、葛根素在各自范围内线性关系良好(r≥0.999),阿魏酸平均回收率为100.3%,RSD=2.0%(n=6),葛根素平均回收率为99.0%,RSD=0.4%(n=6)。结论:本实验建立的质量标准科学、全面、方法可行,可用于心脉通胶囊的质量控制。Objective:Unify and improve the quality standard of xinmaitong capsule.Methods:Using thin layer chromatography(TLC)for identification of Cassiae semen and Sophorae flos,and the contents of ferulic acid and puerarin were determined by high-performance liquid chromatography chromatography(HPLC).Results:The TLC spots were clear,the resolution was good,and the specificity was strong.The linear relationship between ferulic acid and puerarin is good within their respective ranges(r≥0.999).The average recovery rate of ferulic acid is 100.3%,RSD=2.0%(n=6),and the average recovery rate of puerarin is 99.0%,RSD=0.4%(n=6).Conclusion:The quality standard established in this experiment are scientific,comprehensive,and feasible,which can be used for the quality control of xinmaitong capsule.

关 键 词：心脉通胶囊 决明子 槐米 阿魏酸 葛根素 

分 类 号：R286.0[医药卫生—中药学]