体素内不相干运动扩散加权成像在子宫内膜癌中的研究进展  

Research Progress of Intravoxel Incoherent Motion Diffusion-weighted Imaging in Endometrial Carcinoma

作　　者：徐瑜 李文[1] 邓凯[3] XU Yu;LI Wen;DENG Kai(Department of Nuclear Medicine,The First Affiliated Hospital of Shandong First Medical University&Shandong Provincial Qianfoshan Hospital,Jinan 250014,Shandong Province,China;Shandong First Medical University(Shandong Academy of Medical Sciences),Jinan 250014,Shandong Province,China;Department of Radiology,The First Affiliated Hospital of Shandong First Medical University&Shandong Provincial Qianfoshan Hospital,Jinan 250014,Shandong Province,China)

机构地区：[1]山东第一医科大学第一附属医院(山东省千佛山医院)核医学科,山东济南250014 [2]山东第一医科大学(山东省医学科学院),山东济南250014 [3]山东第一医科大学第一附属医院(山东省千佛山医院)放射科,山东济南250014

出　　处：《中国CT和MRI杂志》2024年第7期182-183,共2页Chinese Journal of CT and MRI

基　　金：山东省科技发展计划(2012YD18060)。

摘　　要：子宫内膜癌(endometrial carcinoma,EC)是我国常见的妇科恶性肿瘤之一。早期病变可以通过手术得到有效治疗,一般不需要辅助治疗,但高危和晚期疾病的治疗比较复杂,治疗方案的制定一般与患者的术前病理诊断、组织学类型以及年龄、有无生育要求等有关。分子分型的提出使我们对异质性有了更深入的了解,在提示预后、评估复发风险、指导治疗以及遗传筛查上都有重要意义。体素内不相干运动(intravoxel incoherent motion,IVIM)采用多b值成像,其衍生参数可以从不同角度全面地反映肿瘤的微观情况,进而同时获得肿瘤内部扩散运动和微循环灌注信息。在这篇综述中,我们概述了体素内不相干运动的原理及其对子宫内膜癌的组织学分型和分子分型、肿瘤分级及浸润深度、术前风险分层以及鉴别诊断等的应用价值,为子宫内膜癌患者的精确诊断和个体化治疗提供数据支持。Endometrial cancer is one of the common gynecological malignant tumors in our country.Early lesions can be effectively treated by surgery and generally do not require adjuvant therapy,but the treatments of high-risk and advanced diseases are more complicated.The formulation of treatment plan is generally related to the preoperative pathological diagnosis,histological type,age and fertility requirement of patients.Molecular typing has provided us with a deeper understanding of heterogeneity,which is of great significance in predicting prognosis,assessing recurrence risk,guiding treatment and genetic screening.IVIM adopts multi-B-value imaging,and its derived parameters can comprehensively reflect the microscopic conditions of the tumor from different angles,and then obtain the information of internal diffusion movement and microcirculation perfusion at the same time.In this review,we summarized the principle of IVIM and its application value in tissue typing and molecular typing,tumor grading and depth of invasion,preoperative risk stratification,and differential diagnosis of endometrial cancer,providing data support for accurate diagnosis and individualized treatment of patients with endometrial cancer.

关 键 词：体素不相干运动 扩散加权成像 磁共振成像 子宫内膜肿瘤 

分 类 号：R737.33[医药卫生—肿瘤]