红光诱导菠菜叶提取物催化对羟基苯甲腈的绿色合成——药学类本科生新创实验的研究与探索  

Green Synthesis of p-Hydroxybenzonitrile Catalyzed by Spinach Extracts under Red-Light Irradiation:Research and Exploration of Innovative Experiments for Pharmacy Undergraduates

作　　者：曹陶 房方[1] 李念光[1] 张毅楠 詹其琛 Tao Cao;Fang Fang;Nianguang Li;Yinan Zhang;Qichen Zhan(College of Pharmacy,Nanjing University of Chinese Medicine,Nanjing 210023,China)

机构地区：[1]南京中医药大学药学院,南京210023

出　　处：《大学化学》2024年第5期63-69,共7页University Chemistry

基　　金：2021年度南京中医药大学药学院课程思政示范项目(2021KCSZ008);2022年度南京中医药大学本科教育教学改革研究课题重点项目(NZYJG2022012);江苏高校品牌专业建设工程资助项目(PPZY2015A070)。

摘　　要：在现代有机化学合成反应中,光照是一种重要的反应条件,但是在现行的有机化学实验教材中很少涉及。本新创实验采用微量化方法,借鉴自然界中的光合作用原理,尝试利用可见光红光诱导菠菜叶中的叶绿素,催化对氰基苯硼酸与空气中的氧气发生氧化反应合成对羟基苯甲腈。在我校有机化学实验教学中引入该综合实验,具有如下优点:(1)所用催化剂绿色环保、简单易得,合成过程安全可靠,实验成本低;(2)微量化实验有利于减少环境污染,提高实验安全,节省试剂和时间,减少仪器损耗,有利于培养学生严谨细致的实验作风和习惯;(3)在拓宽学生的知识面和眼界的同时,激发学生的学习兴趣,调动学生的学习积极性。Visible light irradiation is a crucial factor in modern synthetic organic chemistry,yet it is often overlooked in undergraduate organic experiment textbooks.This innovative experiment introduces a microscale approach,inspired by the principles of photosynthesis,to catalyze the oxidation of p-cyanophenylboronic acid to phydroxybenzonitrile using extracts from spinach leaves under red-light irradiation.The incorporation of this comprehensive experiment into our school’s organic chemistry laboratory teaching offers several advantages:(1)The environmentally friendly catalyst is easily accessible,and the synthesis process is safe and reliable with low experimental costs.(2)Microscale experiments contribute to reducing environmental pollution,enhancing laboratory safety,saving reagents and time,minimizing instrument wear and tear,and fostering students’meticulous experimental style and habits.(3)Beyond expanding students’knowledge and horizons,this experiment also ignites their interest in learning and boosts their learning enthusiasm.

关 键 词：菠菜叶 叶绿素 红光 对羟基苯甲腈 绿色合成 

分 类 号：G64[文化科学—高等教育学] O6[文化科学—教育学]