可见光介导多组分一锅法合成仲胺化合物及其机理探究  

Visible-Light-Mediated One-Pot Synthesis of Secondary Amines and Mechanistic Exploration

作　　者：姚震 林冰 田又平 李涛 张文会 刘雄伟 杨武德 Zhen Yao;Bing Lin;Youping Tian;Tao Li;Wenhui Zhang;Xiongwei Liu;Wude Yang(National Demonstration Center for Experimental Chinese Pharmacy(Ethnic Pharmacy)Education(Guizhou University of Traditional Chinese Medicine),Guiyang 550025,China)

机构地区：[1]中药学(民族药学)国家级实验教学示范中心(贵州中医药大学),贵阳550025

出　　处：《大学化学》2024年第5期201-208,共8页University Chemistry

基　　金：中药学(民族药学)国家级实验教学示范中心(贵州中医药大学)本科实践教学质量与教学改革工程项目(示范中心教改合字(2023)04号)。

摘　　要：将有机光化学领域的前沿研究引入到本科实验教学中,以苯甲醛、苯胺和4-异丙基-1,4-二氢吡啶作为起始原料,在温和条件下进行可见光介导的一锅法串联反应,实现了仲胺化合物的制备。实验具有原料廉价易得、反应条件温和、安全性高、操作简单等特点,同时融入绿色化学理念和有机合成方法学的实验探究过程,适用于本科实验教学,可帮助学生在熟练实验操作的同时,增强对光化学反应、一锅法串联反应、自由基反应等知识的理解。本实验将新的科研成果转化为人才培养内容,有助于提高学生的科研创新与实践能力。This experiment integrates cutting-edge research from the field of organic photochemistry into undergraduate laboratory instruction.Utilizing benzaldehyde,aniline,and 4-isopropyl-1,4-dihydropyridines as starting materials,a visible-light-mediated one-pot multicomponent reaction was conducted under mild conditions to yield secondary amines efficiently.The experiment features cost-effective and readily available reagents,simple operation,and mild reaction conditions,alongside incorporating principles of green chemistry and organic synthesis methodology.Suitable for undergraduate laboratory teaching,it provides students with practical skills while deepening their comprehension of topics such as photochemical reactions,one-pot tandem reactions,and free radical processes.This experiment bridges the gap between cutting-edge research and talent cultivation,enhancing students’abilities in scientific research,innovation,and practical application.

关 键 词：光化学 仲胺 一锅法串联反应 自由基反应 

分 类 号：G64[文化科学—高等教育学] O6[文化科学—教育学]