卵巢两性母细胞瘤一例并文献复习  

Ovarian gynandroblastoma:report of a case and literature review

作　　者：田亚玲 王玥元[1] 赵洁[1] 孙建平[1] 田芳[1] Tian Yaling;Wang Yueyuan;Zhao Jie;Sun Jianping;Tian Fang(Department of Pathology,Gansu Provincial Maternity and Child-care Hospital,Lanzhou 730050,China)

机构地区：[1]甘肃省妇幼保健院病理科,兰州730050

出　　处：《中国组织化学与细胞化学杂志》2024年第2期152-154,164,共4页Chinese Journal of Histochemistry and Cytochemistry

基　　金：兰州市科技发展指导性计划项目(2019-ZD-127)。

摘　　要：目的探讨卵巢两性母细胞瘤(ovarian gynandroblastoma,GA)临床病理特征、鉴别诊断及治疗,为病理诊断和临床治疗提供依据。方法回顾性分析1例卵巢两性母细胞瘤的临床病理特征及免疫组织化学表型,并对国内外相关文献进行复习。结果大体标本呈灰黄色乳头状突起,质脆;HE染色见成人型颗粒细胞瘤和支持-间质细胞肿瘤成分;免疫组织化学结果显示calretinin、inhibinα、vimentin呈阳性,CK8/18呈部分阳性,网状纤维染色显示瘤细胞巢周围阳性,MC、CA199、EMA、CKP呈阴性表达,Ki-67增殖指数约10%。结论卵巢两性母细胞瘤是一种十分罕见的卵巢性索-间质肿瘤,其诊断依赖于临床表现、HE染色检测及免疫组织化学分析,治疗方法以手术切除为主。Objective To discuss the clinicopathological characteristics,differential diagnosis,and treatment of ovarian gynandroblastoma(GA),and to provide evidence for pathological diagnosis and clinical treatment.Methods A retrospective analysis of the clinicopathological features and immunohistochemical phenotype of one case of ovarian GA was conducted,along with a review of related literature domestically and internationally.Results The gross specimen presented as gray-yellow papillary protrusions with a brittle texture.HE staining showed components of adult-type granulosa cell tumor and stromal-supportive cell tumor.Immunohistochemistry revealed positive staining for calretinin,inhibinα,and vimentin,partial positivity for CK8/18,positive staining around tumor cell nests with reticular fiber staining,and negative expression for MC,CA199,EMA,and CKP.The Ki-67 proliferation index was approximately 10%.Conclusion Ovarian GA is a very rare ovarian sex cord-stromal tumor.Its diagnosis depends on clinical manifestations,HE staining,and immunohistochemical analysis.The primary treatment method is surgical resection.

关 键 词：两性母细胞瘤 卵巢 鉴别诊断 

分 类 号：R365[医药卫生—病理学]