细胞因子诱导的记忆样NK细胞与实体瘤免疫治疗的研究进展  

Research progress of cytokine induced memory like NK cells and immunotherapy of solid tumors

作　　者：赵瑞东[1] 苏丽娅[1] Zhao Ruidong;Su Liya(Achievement Transformation Department,The Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010050,China)

机构地区：[1]内蒙古医科大学附属医院成果转化科,呼和浩特010050

出　　处：《中国组织化学与细胞化学杂志》2024年第2期165-169,共5页Chinese Journal of Histochemistry and Cytochemistry

基　　金：内蒙古自然科学基金(2018LH08020);内蒙古医科大学实验室开放基金指南性项目(2020ZN52)。

摘　　要：自然杀伤细胞(natural killer cell,NK细胞)是一种先天性淋巴细胞,在抵御病毒感染和肿瘤侵袭中发挥着关键作用,是先天免疫系统的重要组成部分。NK细胞不具有抗原特异性,而近期的研究表明,NK细胞在半抗原暴露、病毒感染或联合细胞因子的激活后,表现出适应性和记忆样特征,后者可通过IL-12/15/18的短暂刺激诱导来实现。与正常NK细胞相比,这些细胞因子诱导的记忆样NK细胞能够长期增殖、存活,并且IFN-γ的产生及对肿瘤细胞的细胞毒性的效应器功能都得以增强,这使其成为肿瘤免疫治疗的优选细胞。在复发性/难治性急性髓系白血病的临床研究证明,细胞因子诱导的记忆样NK细胞过继性治疗是安全并有效的。细胞因子诱导的记忆样NK细胞已经开始肝癌等实体瘤的临床前研究,本文综述目前关于细胞因子诱导的记忆样NK细胞在实体瘤中的临床前研究的最新进展,为实体瘤免的疫治疗提供新思路。Natural killer cells(NK cells)are a kind of innate lymphoid cells that play a crucial role in defending against viral infections and tumor invasion,constituting an essential component of the innate immune system.NK cells lack antigen specificity;however,recent studies have shown that NK cells exhibit adaptive and memory-like features upon exposure to hapten,viral infection,or co-stimulation with cytokines,the latter of which can be induced by transient stimulation with IL-12/15/18.Compared to normal NK cells,these cytokine-induced memory-like NK cells can proliferate and survive long-term,with enhanced effector functions such as IFN-γproduction and cytotoxicity against tumor cells,making them a preferred cell for cancer immunotherapy.Clinical studies in relapsed/refractory acute myeloid leukemia have demonstrated the safety and efficacy of adoptive therapy with cytokine-induced memory-like NK cells.Cytokine-induced memory-like NK cells have begun preclinical studies in solid tumors such as liver cancer,and this review summarizes the latest progress in preclinical studies of cytokine-induced memory-like NK cells in solid tumors,providing new insights into immunotherapy for solid tumors.

关 键 词：细胞因子 记忆样NK细胞 实体瘤 免疫治疗 

分 类 号：R730.51[医药卫生—肿瘤]