酸性代谢环境对心肌细胞分化影响的研究进展  

Influence of Acidic Metabolic Environment on Differentiation of Cardiomyocytes

作　　者：毛嘉豪 周帆 穆军升[1,3] MAO Jiahao;ZHOU Fan;MU Junsheng(Department of Cardiac Surgery,Beijing Anzhen Hospital,Capital Medical University,Beijing Institute of Heart Lung and Blood Vessel Diseases,Beijing 100029,China;Department of Ultrasound,The Third Medical Center of The General Hospital of The People’s Liberation Army,Beijing 100039,China;Department of Cardiac Surgery,The Third Affilited Hospital of Xinxiang Medical University,Xinxiang 453000,Henan,China)

机构地区：[1]首都医科大学附属北京安贞医院心脏外科北京市心肺血管疾病研究所,北京100029 [2]解放军总医院第三医学中心超声科,北京100039 [3]新乡医学院第三附属医院心脏外科,河南新乡453000

出　　处：《心血管病学进展》2024年第6期534-538,共5页Advances in Cardiovascular Diseases

基　　金：国家自然科学基金(82270255)。

摘　　要：以干细胞为基础的心肌再生是治疗心肌梗死的前沿课题,控制干细胞的代谢微环境能影响干细胞向心肌细胞的分化,在临床应用中有着广阔前景。pH值是心肌细胞发育过程中代谢环境的重要指标。乳酸作为主要的酸性代谢产物之一,是调节心肌细胞早期发育阶段酸性代谢环境的关键代谢产物。现就pH值在心肌细胞生存与分化过程中的影响及相关机制的研究进展做一综述。Stem cell-based myocardial regeneration is a frontier topic in the treatment of myocardial infarction.Manipulating the metabolic microenvironment of stem cells can influence their differentiation into cardiomyocytes,which have promising clinical applications.pH is an important indicator of the metabolic environment during cardiomyocyte development.And lactate,as one of the main acidic metabolites,is a major regulator of the acidic metabolic environment during early cardiomyocyte development.Here,we summarize the progress of research into the influence of pH value and lactate on cardiomyocyte survival and differentiation,as well as related mechanisms.

关 键 词：PH值 乳酸 干细胞 心脏分化 酸性代谢环境 

分 类 号：R54[医药卫生—心血管疾病]