黄芪注射液辅助化疗治疗复发性子宫内膜癌的效果  

Effect of Huangqi injection in adjuvant chemotherapy for recurrent endometrial cancer

作　　者：张晶晶[1] 林丽红[1] 周建峰[2] 孟泳圳[1] Zhang Jingjing;Lin Lihong;Zhou Jianfeng;Meng Yongzhen(Department of GynecologyⅣ,Anyang Cancer Hospital,Anyang 455000,China;Heart Disease WardⅡ,Anyang Traditional Chinese Medicine Hospital,Anyang 455000,China)

机构地区：[1]安阳市肿瘤医院妇四科,安阳455000 [2]安阳市中医院心病二区,安阳455000

出　　处：《中国实用医刊》2024年第11期107-110,共4页Chinese Journal of Practical Medicine

摘　　要：目的研究黄芪注射液辅助化疗治疗复发性子宫内膜癌(REC)的效果。方法队列研究。抽取2020年3月至2022年2月安阳市肿瘤医院收治的REC患者88例,按随机数字表法分为对照组与研究组,每组44例。对照组采用常规化疗,研究组在对照组基础上采用黄芪注射液治疗。对比两组治疗效果、治疗前后肿瘤标志物指标(糖类抗原125、人附睾蛋白)、免疫功能[T淋巴细胞(CD4^(+)、CD8^(+)]、卡氏功能状态表(KPS)评分及不良反应。结果研究组总有效率(72.73%,32/44)高于对照组(50.00%,22/44),P<0.05。治疗后,研究组CD4^(+)高于对照组,CD8^(+)低于对照组(P<0.05);治疗后,研究组KPS评分高于对照组(P<0.05)。研究组血小板减少、胃肠道反应、肝功能损害、白细胞减少发生率分别为27.27%(12/44)、27.27%(12/44)、34.09%(15/44)、25.00%(11/44),低于对照组的52.27%(23/44)、47.73%(21/44)、56.82%(25/44)、52.27%(23/44),P<0.05。结论黄芪注射液辅助化疗治疗REC效果显著,能降低肿瘤标志物水平,改善机体免疫功能,提升患者健康水平,减少不良反应的发生。Objective To investigate the effect of Huangqi injection in adjuvant chemotherapy for recurrent endometrial cancer(REC).Methods A total of 88 patients with REC treated in Anyang Cancer Hospital from March 2020 to February 2022 were selected for the cohort study.And they were divided into a control group and a study group by random number table method,with 44 cases in each group.The control group received conventional chemotherapy,and the study group received Huangqi injection based on the treatment of the control group.The therapeutic effects,preoperative and postoperative levels of tumor markers,including carbohydrate antigen 125 and human epididymal protein,immune function assessed by T lymphocytes,including cluster of differentiation 4^(+)(CD4^(+))and cluster of differentiation 8^(+)(CD8^(+)),Karnofsky performance status(KPS)score and incidence of adverse reactions were compared between the two groups.Results The total effective rate of the study group(72.73%,32/44)was higher than that of the control group(50.00%,22/44),P<0.05.After treatment,the study group had higher CD4^(+)and lower CD8^(+)compared with the control group(P<0.05).After treatment,the KPS score in the study group was higher than that in the control group(P<0.05).The incidences of thrombocytopenia,gastrointestinal reactions,liver function damage,and leukopenia in the study group were 27.27%(12/44),27.27%(12/44),34.09%(15/44),and 25.00%(11/44),respectively,which were lower than those in the control group(52.27%,23/44;47.73%,21/44;56.82%,25/44;52.27%,23/44),P<0.05.Conclusions Huangqi injection has a significant effect in adjuvant chemotherapy for REC,which can reduce the levels of tumor markers,improve immune function,improve the health status,and reduce the incidence of adverse reactions.

关 键 词：子宫内膜癌 黄芪注射液 化疗 免疫功能 

分 类 号：R737.33[医药卫生—肿瘤]