三维超声血管血流参数联合血清CA125、TK1对子宫内膜癌患者预后的预测价值  

Predictive Value of Three-Dimensional Ultrasound Vascular Blood Flow Parameters Combined with Serum CA125 and TK1 on the Prognosis of Patients with Endometrial Cancer

作　　者：张荣 问姣 赵佳悦 刘苗 杨晓花 ZHANG Rong;WEN Jiao;ZHAO Jia-yue;LIU Miao;YANG Xiao-hua(Medical Ultrasound Center,Northwest Women's and Children's Hospital,Xi'an,Shaanxi,710061,China;Department of Gynaecology,Northwest Women's and Children's Hospital,Xi'an,Shaanxi,710061,China)

机构地区：[1]西北妇女儿童医院医学超声中心,陕西西安710061 [2]西北妇女儿童医院妇科,陕西西安710061

出　　处：《现代生物医学进展》2024年第11期2130-2133,2124,共5页Progress in Modern Biomedicine

基　　金：陕西省卫生健康科研基金项目(2018D036)。

摘　　要：目的:探讨三维超声血管血流参数联合血清糖类抗原-125(CA125)、胸苷激酶1(TK1)对子宫内膜癌患者预后的预测价值。方法:选择2018年11月至2021年6月于我院行腹腔镜子宫切除术的209例子宫内膜癌患者,术前接受三维超声检查,观察血管血流参数[血管形成指数(VI)、血流指数(FI)和血管形成-血流指数(VFI)],并检测术前血清CA125、TK1水平。术后随访2年,统计预后不良发生情况。根据预后情况将患者分为预后不良组和预后良好组。受试者工作特征(ROC)曲线分析三维超声血管血流参数联合血清CA125、TK1预测子宫内膜癌患者预后不良的价值。结果:随访期间失访2例,发生预后不良54例。预后不良组VI、FI、VFI及血清CA125、TK1水平高于预后良好组(P<0.05)。VI、FI、VFI、CA125、TK1预测子宫内膜癌患者预后不良的曲线下面积分别为0.764、0.775、0.809、0.867、0.807,其中联合预测曲线下面积为0.916,高于各指标单独预测。结论:子宫内膜癌患者的三维超声血管血流参数VI、FI、VFI和血清CA125、TK1水平升高,三维超声血管血流参数联合CA125、TK1检测对子宫内膜癌患者预后不良的预测具有较高价值。Objective:To investigate the predictive value of three-dimensional ultrasound vascular blood flow parameters combined with serum carbohydrate antigen-125(CA125)and thymidine kinase 1(TK1)on the prognosis of patients with endometrial cancer.Methods:209 patients with endometrial cancer who underwent laparoscopic hysterectomy in our hospital from November 2018 to June 2021 were selected,three-dimensional ultrasound was performed before operation,to observe vascular blood flow parameters[vascularization index(VI),blood flow index(FI)and vascularization-blood flow index(VFI)],and preoperative serum CA125 and TK1 levels were detected.Patients were followed up for 2 years after operation,and the incidence of poor prognosis was counted.Patients were divided into poor prognosis group and good prognosis group according to the prognosis.The value of three-dimensional ultrasound vascular blood flow parameters combined with serum CA125 and TK1 in predicting poor prognosis of patients with endometrial cancer were analyzed by receiver operating characteristic(ROC)curve.Results:2 cases were lost during the follow-up period,and 54 cases had poor prognosis.The levels of VI,FI,VFI,serum CA125 and TK1 in poor prognosis group were higher than those in good prognosis group(P<0.05).The area under the curve of VI,FI,VFI,CA125 and TK1 in predicting the poor prognosis of patients with endometrial cancer was 0.764,0.775,0.809,0.867 and 0.807,respectively,the area under the curve of combined prediction was 0.916,which was higher than that of each index alone.Conclusion:The three-dimensional ultrasound vascular blood flow parameters VI,FI,VFI and serum CA125 and TK1 levels in patients with endometrial cancer increased,and three-dimensional ultrasound vascular blood flow parameters combined with CA125 and TK1 detection have high value in predicting the poor prognosis of patients with endometrial cancer.

关 键 词：子宫内膜癌 三维超声 糖类抗原-125 胸苷激酶1 预后 预测价值 

分 类 号：R737.33[医药卫生—肿瘤]