Roles of cancer-associated fibroblast functional heterogeneity in shaping the lymphatic metastatic landscape:new insights and therapeutic strategies  

作　　者：Hanhao Zheng Daiyin Liu Zhicong Liu Mingjie An Yuming Luo Changhao Chen Tianxin Lin 

机构地区：[1]Department of Urology,Sun Yat-sen Memorial Hospital,Sun Yat-sen University,Guangzhou 510003,China [2]Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation,Sun Yat-sen Memorial Hospital,State Key Laboratory of Oncology in South China,Guangzhou 510003,China [3]Department of General Surgery,Guangdong Provincial People’s Hospital,Guangdong Academy of Medical Sciences,Guangzhou 510003,China

出　　处：《Cancer Biology & Medicine》2024年第6期445-450,共6页癌症生物学与医学（英文版）

基　　金：funded by the National Key Research and Development Program of China (Grant No. 2022YFA1305500);the National Natural Science Foundation of China (Grant Nos. 32322023, 82173272, 81825016, and 82173230);the Key Areas Research and Development Program of Guangdong (Grant Nos. 2022B1515120086 and 2022A1515140175);the Science and Technology Program of Guangzhou,China (Grant No. 2023A04J2206)。

摘　　要：Lymph node (LN) metastasis is a process in which cancer cells travel from primary tumors to LNs via the lymphatic system,then proliferate and spread within the LNs. In most cancers,LN metastasis is a major mode of cancer dissemination,and a critical indicator of cancer progression and worsening prognosis1. The occurrence of LN metastasis indicates that the tumor has invaded the lymphatic system.

关 键 词：metastasis LYMPHATIC LANDSCAPE 

分 类 号：R730.5[医药卫生—肿瘤]