含糖饮料消费和抑郁风险:前瞻性队列研究的Meta分析  

SUGAR-SWEETENED BEVERAGES CONSUMPTION AND THE RISK OF DEPRESSION:A META-ANALYSIS OF PROSPECTIVE COHORT STUDIES

作　　者：谢亦莎 环冬香 马婕妤 栾文雪 尚思源 李新莉[1] XIE Yi-sha;HUAN Dong-xiang;MA Jie-yu;LUAN Wen-xue;SHANG Si-yuan;LI Xin-li(Department of Nutrition and Food Hygiene,School of Public Health,Suzhou Medical College of Soochow University,Suzhou 215123,China)

机构地区：[1]苏州大学苏州医学院公共卫生学院营养与食品卫生学系,苏州215123

出　　处：《营养学报》2024年第2期183-191,共9页Acta Nutrimenta Sinica

基　　金：国家自然科学基金(No.81973023,81673150)。

摘　　要：目的已发表的研究对含糖饮料(SSBs)消费与抑郁风险增加之间的关系得出了不一致的结论,为此,本Meta分析拟进一步评估SSBs摄入与抑郁风险之间的关系。方法检索PubMed、Web of Science、Embase、Cochrane、中国期刊全文数据库(CNKI)、万方数据库,搜集有关SSBs消费与抑郁风险的前瞻性队列研究,检索时间为建库至2023年3月1日。采用DerSimonian-Laird法进行异质性检验。采用随机效应模型进行效应量的合并,并通过亚组分析和敏感性分析寻找异质性的来源。通过漏斗图和Egger检验是否存在发表偏倚,并采用剪补法(Duval and Tweedie nonparametric trimandfillmethod)探究发表偏倚对结论的影响。结果本Meta分析纳入了7项队列研究,共294910名参与者。Meta分析结果显示,与SSBs摄入量最低组相比,摄入量最高组发生抑郁的综合风险为1.28(95%CI:1.08-1.51)。亚组分析结果显示,SSBs消费与抑郁风险的关联存在性别、年龄、地区和随访时间的差异。敏感性分析显示,本次所纳入的研究对SSBs摄入与抑郁风险的合并效应均没有过度影响。结论过量摄入SSBs有增加抑郁风险的可能,但仍需进一步证实。Objective Published studies have drawn inconsistent conclusions on the association between sugar-sweetened beverages(SSBs)consumption and the risk of depression.Therefore,we conducted a meta-analysis to further evaluate the relationship between SSBs intake and the risk of depression.Methods Literatures related to prospective cohort studies reporting the association between SSBs consumption and the risk of depression were searched from PubMed,Web of Science,Embase,Cochrane,CNKI and Wanfang database up to March 1,2023.Heterogeneity testing was performed by DerSimonian-Laird method.Random-effected model was used to calculate the pooled risk estimate,and the causes of heterogeneity were found by subgroup analysis and sensitivity analysis.Publication bias was assessed by funnel plot and Egger test,and the impact on the results was evaluated by Duval and Tweedie nonparametric trim and fill method.Results A total of 7 cohort studies with 294,910 participants were included in the present meta-analysis.The results indicated that the combined risk of depression was 1.28(95%CI:1.08-1.51)in the group with the highest SSBs intake compared to the lowest group.The results of subgroup analysis showed significant differences in the associations between SSBs consumption and depression risk by sex,age,location,and duration of follow-up.Sensitivity analysis didn't support the excessive impact of the included study on the combined effects of SSBs consumption and depression risk.Conclusion Excessive consumption of SSBs endows higher risk of depression,but further confirmation is needed.

关 键 词：含糖饮料 抑郁风险 前瞻性队列研究 META分析 

分 类 号：R151.41[医药卫生—营养与食品卫生学]