先天性缺牙治疗的研究进展  

Research advances in treatment of tooth agenesis

作　　者：耿晨昕 刘洋[1] 韩冬[1] Geng Chenxin;Liu Yang;Han Dong(Department of Prosthodontics,Peking University School and Hospital of Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical Devices&Beijing Key Laboratory of Digital Stomatology,Beijing 100081,China)

机构地区：[1]北京大学口腔医学院,口腔医院修复科,国家口腔医学中心,国家口腔疾病临床医学研究中心口腔生物材料和数字诊疗装备国家工程研究中心,口腔数字医学北京市重点实验室,100081

出　　处：《中国口腔种植学杂志》2024年第3期224-230,共7页Chinese Journal of Oral Implantology

基　　金：国家自然科学基金(82270944)。

摘　　要：先天性缺牙是人类最常见的牙发育异常,影响患者的咀嚼、发音、美观及颌面部发育。由于该疾病的特殊特点,其治疗历时久、花费高,给患者带来心理和经济的双重负担。治疗方法包括儿科、正畸、颌面外科、修复、种植等多学科协作的序列治疗,以及靶向分子治疗和组织工程技术等新兴手段。本文综述了先天性缺牙的疾病特点、传统治疗方式的新进展以及新兴的治疗方法,简述了不同治疗方法的治疗效果,旨在为先天性缺牙患者的临床治疗提供有意义的信息。Tooth agenesis is the most common dental developmental anomaly in humans,which can cause significant chewing,pronunciation,aesthetic and craniofacial development problems.Due to the unique characteristics of tooth agenesis,its treatment is very time-consuming and costly,imposing huge economic burdens and mental stress on patients.The treatments include a sequential therapeutic strategy with a multidisciplinary team of pediatric dentistry,prosthodontics,oral and maxillofacial surgery,orthodontics,oral implantology,and other backgrounds,as well as emerging methods such as targeted molecular therapy and tissue engineering.This review provides an update on the knowledge on the characteristics of tooth agenesis,traditional treatments,and the rising fields of molecular therapy and tissue engineering.We also discuss the treatment effects of each method,aiming to provide a reference for the treatment of tooth agenesis.

关 键 词：先天性缺牙 多学科序列治疗 牙种植 分子靶向治疗 牙再生 

分 类 号：R781[医药卫生—口腔医学]