乳腺癌组织ZIC5蛋白表达与临床病理特征和手术预后的关系  

Expression of ZIC5 protein in breast cancer and its relationship with clinicopathological characteristics and surgical prognosis

作　　者：张建业 马英 祁占花 ZHANG Jian-ye;MA Ying;QI Zhan-hua(First Department of Surgery,Qinghai Provincial Communications Hospital,Xining 810001,China)

机构地区：[1]青海省交通医院外一科,青海西宁810001

出　　处：《中国现代普通外科进展》2024年第6期458-462,共5页Chinese Journal of Current Advances in General Surgery

摘　　要：目的:探究乳腺癌组织小脑锌指结构5(ZIC5)蛋白表达与临床病理特征、手术预后的关系。方法:选取2016年6月至2017年12月本院收治的128例乳腺癌患者,采用免疫组化学法检测ZIC5蛋白表达。比较乳腺癌患者癌组织和切缘正常组织ZIC5蛋白阳性表达率;比较不同临床病理特征乳腺癌患者ZIC5蛋白阳性表达率;分析乳腺癌患者癌组织ZIC5蛋白表达与手术预后的关系。结果:乳腺癌组织ZIC5蛋白阳性表达率高于切缘正常组织。乳腺癌患者术后的生存率为81.37%,TNM分期Ⅲ~Ⅳ期、未/低分化、肿瘤直径≥2 cm、浸润深度T3~T4、有淋巴结转移、ZIC5蛋白阳性表达均为乳腺癌手术预后不良的危险因素(RR=4.405、5.153、4.520、2.211、3.137、6.079,P<0.05);乳腺癌组织ZIC5蛋白阴性表达患者生存率高于ZIC5蛋白阳性表达患者(P<0.05)。结论:乳腺癌组织ZIC5蛋白阳性表达率较切缘正常组织升高,且癌组织ZIC5蛋白表达与临床分期、肿瘤分化程度、肿瘤大小、浸润深度、淋巴结转移有关,均为乳腺癌手术预后不良的危险因素。ZIC5蛋白可能成为精准治疗乳腺癌的靶向位点。Objective:To explore the relationship between the expression of cerebellar zinc finger structure 5(ZIC5)protein in breast cancer and its clinicopathological characteristics,surgical prognosis.Methods:A total of 128 breast cancer patients,who were admitted to our hospital between June 2016 and December 2017,were enrolled in this study.Immunohistochemistry was employed to assess the expression of ZIC5 protein.The positive expression rate of ZIC5 protein in breast cancer tissues was compared with that in normal surgical margin tissues.Additionally,an analysis was conducted to explore the association between the expression of ZIC5 protein and various clinical pathological characteristics of breast cancer patients,as well as its correlation with prognosis.Results:The positive expression rate of ZIC5 protein in breast cancer tissue was higher than that in normal tissue of resection margin.The postoperative survival rate of breast can-cer patients was 81.37%.TNM stageⅢ~Ⅳ,undifferentiated/poorly differentiated,tumor diam-eter≥2 cm,invasion depth T3~T4,lymph node metastasis,ZIC5 protein positive expression were all risk factors for poor prognosis of breast cancer surgery.(RR=4.405,5.153,4.520,2.211,3.137,6.079,P<0.05).The survival rate of patients with negative ZIC5 protein expression in breast cancer tissue was higher than that of patients with positive ZIC5 protein expression(P<0.05).Conclusion:The positive expression rate of ZIC5 protein in breast cancer tissue is higher than that in nor-mal tissue of resection margin,and the expression of ZIC5 protein in cancer tissue is related to clinical stage,tumor differentiation,tumor size,invasion depth,and lymph node metastasis.The above indicators are risk factors for poor prognosis of breast cancer surgery.

关 键 词：乳腺肿瘤 小脑锌指结构5 临床病理特征 手术预后 

分 类 号：R737.9[医药卫生—肿瘤]