以环己酮制备的绿色工艺优化改进为例探讨有机化学实验教学改革  

Taking the Green Process Optimization and Improvement of Cyclohexanone Preparation as an Example to Investigate the Reform of Organic Chemistry Experimental Teaching

作　　者：谢艳军 龚慧玲 邓晋 童家俊 罗王虎 谭建平 易兵[1] XIE Yanjun;GONG Huiling;DENG Jin;TONG Jiajun;LUO Wanghu;TAN Jianping;YI Bing(College of Materials and Chemical Engineering,Hunan Institute of Engineering,Xiangtan 411104,China)

机构地区：[1]湖南工程学院材料与化工学院,湖南湘潭411104

出　　处：《生物化工》2024年第3期152-154,172,共4页Biological Chemical Engineering

基　　金：湖南省自然科学基金(2023JJ30189);湖南工程学院教学改革研究项目(22045,23004);湖南工程学院研究生科研创新项目(YC202215)。

摘　　要：本文在原实验教材的基础之上,对环己酮的制备工艺进行绿色化改进。采用环己醇为反应物,氯铬酸吡啶盐为氧化剂,无须催化剂,可高效制备环己酮。通过考察氧化剂的用量、反应温度及反应时间对环己酮产率的影响,实验得到最优工艺条件为环己醇42 mmol,氯铬酸吡啶盐35 mmol,反应温度60℃,反应时间80 min,环己酮的产率为81%。与传统实验方案相比,该方案所用氧化剂稳定、低毒,试剂用量有所降低,符合绿色化学发展要求。On the basis of the original experimental textbook,this paper intends to make green improvements to the preparation process of cyclohexanone.Using cyclohexanol as the starting material and pyridine chlorochromate as the oxidant,cyclohexanone is prepared efficiently without addition of any catalysts.The effects of the amount of oxidizing agent,reaction temperature as well as the reaction time for the yield of cyclohexanone are investigated.The optimum process conditions are obtained as follows:cyclohexanol of 42 mmol,pyridine chlorochromate of 35 mmol,reaction temperature of 60℃,reaction time of 80 min,and the highest yield of cyclohexanone is 81%.The oxidant used in this paper is stable and low toxicity,and the amount of reagents is greatly reduced,which is in according with the development direction of green chemistry.

关 键 词：环己酮 有机化学 绿色工艺 实验教学改革 

分 类 号：G64[文化科学—高等教育学]