A facile strategy to construct MOF-based nanocatalyst with enhanced activity and selectivity in oxytetracycline degradation  

作　　者：Yanjing Ke Jiaxing Zhang Xin Peng Zhiyi Zhang Xu Wang Wei Qi Mengfan Wang 

机构地区：[1]School of Life Sciences,Faculty of Medicine,School of Chemical Engineering and Technology,Tianjin University,Tianjin 300072,China [2]The Co-Innovation Centre of Chemistry and Chemical Engineering of Tianjin,Tianjin 300072,China [3]Tianjin Key Laboratory of Membrane Science and Desalination Technology,Tianjin 300350,China

出　　处：《Nano Research》2024年第7期5863-5871,共9页纳米研究（英文版）

基　　金：the National Natural Science Foundation of China(Nos.22178260 and 21676191).

摘　　要：Recently,many efforts have been dedicated to construct artificial catalysts with enzyme-like activity.However,it is still a big challenge to endow artificial catalysts with specific substrate selectivity.In this study,we developed a facile strategy to construct a MIL-53(Fe)-based nanocatalyst with designable selectivity in the degradation of oxytetracycline(OTC).Through the Fe–O–P conjunction,oxytetracycline aptamer(OA)can be easily anchored on MIL-53(Fe)to provide the specific site for OTC binding.We verified that the obtained MIL-53(Fe)-Apt nanocatalyst displayed enhanced catalytic ability in the degradation of OTC,whereas obvious suppression toward other substrate analogues.This performance therefore brings about an anticipated selectivity toward OTC.Moreover,we highlighted that the configuration of aptamers on MIL-53(Fe)can be modulated through varying conjunction mode.Structure–function analysis revealed that aptamer configuration affects the local concentration of substrate around catalytic site,which thus decides the catalytic performance toward OTC.This work presented a facile and promising strategy for developing artificial catalysts with designable selectivity.

关 键 词：MIL-53(Fe) APTAMER Fe-O-P catalytic selectivity OXYTETRACYCLINE 

分 类 号：O64[理学—物理化学]