Remodel the perifollicular microenvironment via Minoxidil-loaded microneedle patch and cold atmospheric plasma for treating androgenetic alopecia  

作　　者：Hao Chen Xianzhe Tang Yueye Huang Chen Chen Yuheng Yang Chaojie Hao Wenqi Xie Tingjing Huang Xiaofeng Cheng Qingnan Xu Shicong Huang Zhi Ye Xucong Lin Zhaowei Chen Zhitong Chen 

机构地区：[1]MOE Key Laboratory for Analytical Science of Food Safety and Biology,and New Cornerstone Science Laboratory,College of Chemistry,Fuzhou University,Fuzhou 350108,China [2]Institute of Biomedical and Health Engineering,Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055,China [3]Advanced Therapeutic Center,National Innovation Center for Advanced Medical Devices,Shenzhen 518000,China [4]Department of Chemistry,University College London,London WC1H 0AJ,UK [5]Engineering Technology Research Center on Reagent and Instrument for Rapid Detection of Product Quality and Food Safety in Fujian Province,College of Chemistry,Fuzhou University,Fuzhou 350108,China [6]Key Laboratory of Biomedical Imaging Science and System,Chinese Academy of Sciences,Shenzhen 518055,China

出　　处：《Nano Research》2024年第7期6411-6419,共9页纳米研究（英文版）

基　　金：supported by the National Key Research and Development Program of China(Nos.2022YFE0126000(Z.T.C.),and 2020YFA0210800(Z.W.C.));the National Natural Science Foundation of China(Nos.22277011(Z.W.C.),and 22107019(Z.W.C.));the Major Project of Science and Technology of Fujian Province(No.2020HZ06006(Z.W.C.));the Guangdong Basic and Applied Basic Research Foundation(No.2022A1515011129((Z.T.C.)).

摘　　要：Androgenetic alopecia(AGA)is a chronic and progressive form of hair loss characterized by vascular degeneration in the perifollicular microenvironment,leading to cell apoptosis and eventual loss of hair follicles(HFs).Traditional therapeutic formulations,such as Minoxidil(MXD)tincture,have limitations in reshaping the perifollicular microenvironment and exhibit limited effectiveness.Here,we report a multi-synergistic therapeutic platform for high-performance hair regeneration therapy.The platform combines microneedle(MN)patches loaded with MXD-encapsulated nanostructured lipid carriers(MXD-NLC-MNs)and cold atmospheric plasma(CAP).The MNs’mechanical strength enables efficient transdermal delivery of MXD to the targeted dermal papilla cells,promoting cell proliferation.Furthermore,in collaboration with MXD,the mechanical stimulation exerted by MN application synergistically upregulates the expression of vascular endothelial growth factor,leading to neoangiogenesis.Meanwhile,the transient microchannels in the skin created by MNs facilitate the transdermal delivery of CAPgenerated nitric oxide(NO)to the sites of HF lesions,whereby the synergistic interaction between MXD and NO boosts perifollicular vasodilation.Consequently,the perifollicular microenvironment can be effectively reshaped to accelerate hair regeneration in AGA murine models.This multi-synergistic combination therapy strategy would hold great promise for effectively treating AGA and promoting hair regrowth.

关 键 词：NANOMEDICINE androgenetic alopecia MICRONEEDLE cold atmospheric plasma drug delivery 

分 类 号：R758.71[医药卫生—皮肤病学与性病学]