A low-swelling hydrogel as a multirole sealant for efficient dural defect sealing and prevention of postoperative adhesion  

作　　者：Xueliang Cheng Zhen Zhang Hui Ren Zheng Zou Yu Zhang Yang Qu Xuesi Chen Jianwu Zhao Chaoliang He 

机构地区：[1]CAS Key Laboratory of Polymer Ecomaterials,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China [2]Department of Orthopedics,The Second Norman Bethune Hospital of Jilin University,Changchun 130014,China [3]School of Applied Chemistry and Engineering,University of Science and Technology of China,Hefei 230026,China

出　　处：《National Science Review》2024年第6期287-300,共14页国家科学评论（英文版）

基　　金：supported by the National Natural Science Foundation of China(52173147,51973218 and 22105198);the Scientific and Technological Development Projects of jilin Province(20210204136YY);the Jilin Province Youth Science and Technology Talent Support Project(QT202214);the Rural and Social Development Branch,Changchun Science and Technology Bureau(21ZGY23).

摘　　要：Dural defects and subsequent complications, including cerebrospinal fluid (CSF) leakage, are common inboth spine surgery and neurosurgery, and existing clinical treatments are still unsatisfactory. In this study, atissue-adhesive and low-swelling hydrogel sealant comprising gelatin and o-phthalaldehyde(OPA)-terminated 4-armed poly(ethylene glycol) (4aPEG-OPA) is developed via the OPA/aminecondensation reaction. The hydrogel shows an adhesive strength of 79.9 ± 12.0 kPa on porcine casing and aburst pressure of 208.0 ± 38.0 cmH_(2)O. The hydrogel exhibits a low swelling ratio at physiologicalconditions, avoiding nerve compression in the limited spinal and intracranial spaces. In rat and rabbitmodels of lumbar and cerebral dural defects, the 4aPEG-OPA/gelatin hydrogel achieves excellentperformance in dural defect sealing and preventing CSF leakage. Moreover, local inflammation, epiduralfibrosis and postoperative adhesion in the defect areas are markedly reduced. Thus, these findings establishthe strong potential of the hydrogel sealant for the effective watertight closure of dural defects.

关 键 词：hydrogel sealant watertight closure low swelling o-phthalaldehyde chemistry dural sealing 

分 类 号：R730.5[医药卫生—肿瘤]