弥漫大B细胞淋巴瘤中ERK和p38的表达及临床病理学意义  

Expression of ERK and p38 in diffuse large B-cell lymphoma and their clinicopathological significance

作　　者：马明福[1] 李君娜 于靖雯 王小树 穆海拜提·阿卜拉江 崔文丽[1] MA Ming-fu;LI Jun-na;YU Jing-wen;WANC Xiao-shu;MU Haibaiti·Abulajiang;CUI Wen-li(Departm of Pathology,the First Afiliated Hospital of Xinjiang Medical University,Wulumuqi 830054,China;Department of Pathology,Moyu County People's Hospital,Moyu 848100 China)

机构地区：[1]新疆医科大学第一附属医院病理科,乌鲁木齐830054 [2]新疆墨玉县人民医院病理科,新疆墨玉848100

出　　处：《诊断病理学杂志》2024年第6期513-516,536,共5页Chinese Journal of Diagnostic Pathology

基　　金：国家自然科学基金(82060038);国家自然科学基金(82360046)。

摘　　要：目的探讨ERK和p38在弥漫大B细胞淋巴瘤(DLBCL)中的表达与各临床病理指标之间的关系,及其与预后的相关性。方法运用免疫组化检测152例弥漫大B细胞淋巴瘤中ERK和p38阳性表达情况,应用SPSS 23.0软件分析其与各临床病理指标的关系。结果在DLBCL中,ERK、p38的阳性率分别为68.4%、50%,ERK、p38在肿瘤直径>4 cm中阳性表达率高,差异均有统计学意义,且均与肿瘤直径显著正相关。p38在结内病变和结外侵犯>2个淋巴结阳性表达率更高,差异有统计学意义,且与结外侵犯正相关,与原发部位负相关。多因素分析中,表现状态评分、LDH水平和R-CHOP治疗是影响DLBCL患者总生存期的独立危险因素。结论这些发现表明ERK和p38在DLBCL中的致癌作用,提示它们是DLBCL潜在的治疗靶点。Objective To investigate the relationship between the expression of ERK and p38 in diffuse large B-cell lymphoma(DLBCL)and various clinicopathological indicators,as well as the correlation with prognosis.Methods The positive expression of ERK and p38 in 152 cases of DLBCL was detected by immunohistochemistry.The relationship between ERK and P38 was analyzed by SPSS 23.0 software.Results In DLBCL,the positive rates of ERK and p38 were 68.4%and 50%,respectively.The positive rates of ERK and p38 were high in tumor diameter>4 cm,and the differences were statistically significant,and both were significantly positively correlated with tumor diameter.The positive expression rate of p38 was higher in nodal lesions and extranodal invasion>2 lymph nodes,and the difference was statistically significant,and it was positively correlated with extranodal invasion and negatively correlated with the primary site.In multivariate analysis,performance status score,LDH level,and R-CHOP treatment were independent risk factors for overall survival in DLBCL patients.Conclusion These findings indicate the carcinogenic role of ERK and p38 in DLBCL,suggesting that they are potential therapeutic targets for DLBCL.

关 键 词：弥漫大B细胞淋巴瘤 ERK P38 临床病理 靶点 

分 类 号：R733.4[医药卫生—肿瘤]