胃底腺来源肿瘤15例临床病理分析  

Gastric fundus gland derived tumors:a clinicopathological analysis of fifteen cases

作　　者：马强 张渝 唐丹 肖华亮 MA Qiang;ZHANG Yu;TANG Dan;XIAO Hua-liang(Department of Pathology,Army Special Medical Cente Chongqing 400042,China;Department of Pathology,Jiangbei District People's Hospital,Chongqing 400020,China)

机构地区：[1]陆军特色医学中心病理科,重庆400042 [2]重庆市江北区人民医院病理科,重庆400020

出　　处：《诊断病理学杂志》2024年第6期521-526,共6页Chinese Journal of Diagnostic Pathology

摘　　要：目的探讨胃底腺来源肿瘤包括胃泌酸腺腺瘤(OGA)、胃底腺型腺癌(GA-FG)及胃底腺黏膜型腺癌(GA-FGM)的临床病理特征与鉴别诊断。方法收集陆军特色医学中心及重庆市江北区人民医院2020-01—2023-05诊治的15例胃底腺来源肿瘤,分析其病理形态特征、免疫表型及治疗与预后情况并复习相关文献。结果15例患者中男性9例,女性6例,年龄52~76岁,平均年龄62岁;(OGA)5例,(GA-FG)9例,(GA-FGM)1例。所有患者均获得2~30个月随访,均未见复发及转移。结论胃底腺来源肿瘤较少见,OGA/GA-FG其组织学形态、免疫表型具有明显相似性,OGA可能是GA-FG的早期病变;内镜下完整切除是首选治疗方式。胃底腺黏膜型腺癌(GA-FGM)更为罕见,暂未收录到WHO消化系统肿瘤分类中,其生物学行为有待更多病例的进一步观察和探讨。Objective To investigate the clinical and pathological characteristics,diagnosis,and differential diagnosis of gastric fundus gland derived tumors,including oxyntic gland adenoma(OGA),gastric adenocarcinoma of fundic gland type(GA-FG)and gastric adenocarcinoma of fundic-gland mucosa type(GA-FGM).Methods The clinical and pathological data of 15 cases of gastric fundus gland derived tumors diagnosed by Army Special Medical Center and Chongqing Jiangbei District People's Hospital from January 2020 to May 2023 were collected,and the pathological morphological characteristics,immunohistochemical test result,treatment and prognosis,were analyzed combined with the literature.Results Among the 15 patients,there were 9 males and 6 females,aged 52-76 years,with an average age of 62 years.The tumor was mainly located in the fundus and body of the stomach;OGA in 5 cases,GA-FG in 9 cases,and GA-FGM in 1 case;All patients had 2 to 30 months follow-up and showed no recurrence or metastasis.Conclusion Gastric fundus gland derived tumors are rare,OGA/GA-FG its histological morphology and immune phenotype have obvious similarity.OGA may be an early lesion of GA-FG,complete endoscopic resection of the lesion is the preferred treatment.And gastric adenocarcinoma of fundic-gland mucosa type(GA-FGM)is more rare,This tumor is not yet included in the WHO digestive system tumor classification.Its biological behavior needs to be further observed and explored in more cases.

关 键 词：胃肿瘤 胃底腺来源肿瘤 临床病理诊断 鉴别诊断 

分 类 号：R735.2[医药卫生—肿瘤]