子宫内膜癌组织LAMB3、FABP6表达及其预后价值  

Expression of LAMB3 and FABP6 in endometrial cancer tissue and their prognostic value

作　　者：吕元杰 周玮玮[1] 张景瑜 冯婧[2] 邢荣格[1] 苗志刚[1] LV Yuan-jie;ZHOU Wei-wei;ZHANG Jing-yu;FENG Jing;XING Rong-ge;MIAO Zhi-gang(Department Pathology,Central Hospital of Cangzhou,Cangzhou 061000,China;Department of Gynecology,Central Hospital of Cangzhou,Cangzhou 061000,China)

机构地区：[1]河北省沧州市中心医院病理科,河北沧州061000 [2]河北省沧州市中心医院妇科,河北沧州061000

出　　处：《诊断病理学杂志》2024年第4期304-308,312,共6页Chinese Journal of Diagnostic Pathology

基　　金：沧州市重点研发计划指导项目:采用免疫组化方法用于宫内膜样腺癌分子分型的研究(213106037)。

摘　　要：目的探讨层黏连蛋白亚基β3(LAMB3)、脂肪酸结合蛋白6(FABP6)在子宫内膜癌组织中的表达及预后价值。方法以本院接受手术治疗的113例子宫内膜癌患者术中收集的子宫内膜癌组织及其癌旁组织为研究样本。检测LAMB3、FABP6在组织中的表达情况;分析LAMB3和FABP6与患者预后的关系;分析影响子宫内膜癌患者预后的危险因素。结果子宫内膜癌组织中LAMB3、FABP6表达水平高于癌旁组织(P<0.05)。子宫内膜癌组织中LAMB3与FABP6表达具有正相关关系(P<0.05)。LAMB3低表达组的生存率高于高表达组(P<0.05),FABP6低表达组的生存率高于高表达组(P<0.05);FIGO分期为Ⅲ期、肌层浸润深度≥1/2、淋巴结转移、低分化、POLE无突变型、LAMB3高表达及FABP6高表达是子宫内膜癌患者3年内死亡的危险因素(P<0.05)。结论LAMB3、FABP6在子宫内膜癌组织中异常高表达,两者与患者临床病理特征及预后密切相关。Objective To investigate the expression and prognostic value of laminin subunitβ3(LAMB3)and fatty acid-binding protein 6(FABP6)in endometrial cancer.Methods Endometrial cancer and its adjacent tissues from 113 endometrial cancer patients who underwent surgical treatment in our hospital collected during surgery were selected as study samples.The expression of LAMB3 and FABP6 in tissues was dsetected;the relationship between LAMB3 and FABP6 and patient prognosis was analyzed;the risk factors affecting the prognosis of endometrial cancer patients were determined.Results The expression levels of LAMB3 and FABP6 in endometrial cancer tissue were higher than those in the adjacent tissues(P<0.05).There was a positive correlation between LAMB3 and FABP6 expression in endometrial cancer tissue(P<0.05).The survival rate of the low expression LAMB3 group was higher than that of the high expression LAMB3 group(P<0.05),and the survival rate of the low expression FABP6 group was higher than that of the high expression FABP6 group(P<0.05);that FIGO stageⅢ,depth of myometrial invasion≥1/2,lymph node metastasis,low differentiation,POLE no mutant,high expression of LAMB3,and high expression of FABP6 were risk factors for death within 3 years in endometrial cancer patients(P<0.05).Conclusion LAMB3 and FABP6 are abnormally highly expressed in endometrial cancer tissue,and they are closely related to the clinical pathological characteristics and prognosis of patients.

关 键 词：子宫内膜癌 层黏连蛋白亚基β3 脂肪酸结合蛋白6 预后 

分 类 号：R733.3[医药卫生—肿瘤]