免疫学教学中“聚糖与免疫”相关内容的引入与探讨  

Introduction and discussion of “glycans and immunity” in Immunology teaching

作　　者：魏湲颜 杨悦蓉 徐金强 江建海 WEI Yuanyan;YANG Yuerong;XU Jinqiang;JIANG Jianhai(NHC Key Laboratory of Glycoconjuates Research,Department of Biochemistry and Molecular Biology,School of Basic Medical Sciences,Fudan University,Shanghai 200030,China)

机构地区：[1]复旦大学基础医学院生物化学与分子生物学系,卫生健康委员会糖复合物重点实验室,上海200030

出　　处：《生命的化学》2024年第6期1133-1137,共5页Chemistry of Life

基　　金：复旦大学本科教学改革项目(FD2024A159)。

摘　　要：聚糖作为蛋白质翻译后修饰的重要类型,在机体中发挥着重要的生物学功能。当疾病发生时通常伴随着聚糖结构与丰度的改变。在机体进行免疫应答、免疫调节过程时,聚糖也发挥着免疫识别、信号转导和细胞黏附等作用。免疫学作为一门重要的基础课程,目前的课本中未涉及“聚糖与免疫”相关知识。本文阐述了聚糖在免疫过程中的相关机制,并对聚糖在各种免疫疾病中的应用及其在免疫学课本中的引入进行了探讨。免疫学中“聚糖与免疫”相关内容的引入有利于学生对前沿科学的了解,并能提高学生的核心竞争力。Glycans, as an important type of protein post-translational modification, play important biological functions in the body, and often accompanied by changes in structure and abundance when diseases occur.During the immune response and regulation process, glycans also play roles in immune recognition, signal transduction, and cell adhesion. Immunology, as an important foundational course, currently does not involve knowledge related to “glycans and immunity” in textbooks. This paper elaborates on the relevant mechanisms of glycans in the immune process, and explores their applications in various immune diseases and their introduction in Immunology textbooks. The introduction and discussion of “glycans and immunity” in immunology is beneficial for students to understand the frontiers of scientific research and improve their core competitiveness.

关 键 词：聚糖与免疫 免疫学教改 糖生物学 

分 类 号：R-4[医药卫生] G642[文化科学—高等教育学]