神经元特异性烯醇化酶和细胞角蛋白19片段检测在肺癌诊断及疗效评估中的应用  

Application of Neuron Specific Enolase and Cytokeratin 19 Fragment Detection in the Diagnosis and Efficacy Evaluation of Lung Cancer

作　　者：任晓燕 方献英 宋波 REN Xiao-yan;FANG Xian-Ying;SONG Bo(Department of Oncology,Xinyang Central Hospital,Xinyang 464000,China)

机构地区：[1]信阳市中心医院肿瘤内科,信阳464000

出　　处：《四川解剖学杂志》2024年第2期34-36,共3页Sichuan Journal of Anatomy

摘　　要：目的:探讨血清神经元特异性烯醇化酶(NSE)、细胞角蛋白19片段(CYFRA21-1)检测,在肺癌患者诊断及疗效评估中的应用.方法:选取2019年5月至2022年6月本院收治的94例肺癌患者为研究对象,并将其纳入肺癌组.另选取75例健康体检受试者纳入对照组.根据治疗疗效评估结果,进一步将肺癌组患者分为缓解组(n=75)和非缓解组(n=19).检测3组受试者的血清NSE、CYFRA21-1水平,分析血清NSE、CYFRA21-1水平在肺癌患者诊断及疗效评估中的作用.结果:肺癌组患者血清NSE、CYFRA21-1水平明显高于对照组,差异具有统计学意义(P<0.05).肺小细胞癌患者的血清NSE表达水平明显高于肺腺癌、肺鳞癌患者,血清CYFRA21-1水平在肺鳞癌患者中的表达水平明显高于肺腺癌及肺小细胞癌患者,差异均有统计学意义(P<0.05).肺癌组患者中,缓解组血清NSE、CYFRA21-1水平低于非缓解组,差异有统计学意义(P<0.05).结论:血清NSE和CYFRA21-1水平检测,在肺癌诊断及疗效评估中具有重要意义.Objective:To explore the application of neuron specific enolase(NSE)and Cytokeratin 19 fragment(CYFRA21-1)detection in the diagnosis and efficacy evaluation of lung cancer.Methods:A total of 94 lung cancer patients who were treated in our hospital from May 2019 to June 2022 were selected as the research objects and included into lung cancer group.In addition,75 healthy people were selected and included into control group.The patients in lung cancer group were further divided into remission group(n=75)and non-remission group(n=19)based on the evaluation of treatment efficacy.The levels of serum NSE and CYFRA21-1 were detected in all research objects.The application of NSE and CYFRA21-1 in the diagnosis and efficacy evaluation of lung cancer patients were analyzed.Results:The serum levels of NSE and CYFRA21-1 in lung cancer group were significantly higher than those in control group,and the difference was statistically significant(P<0.05).The level of NSE in lung small cell carcinoma was significantly higher than that in lung adenocarcinoma and lung squamous cell carcinoma,and the level of CYFRA21-1 in lung squamous cell carcinoma was significantly higher than that in lung adenocarcinoma and lung small cell carcinoma,and the differences were statistically significant(P<0.05).The levels of NSE and CYFRA21-1 in the remission group were lower than those in the non-remission group,and the differences were statistically significant(P<0.05).Conclusion:The detection of NSE and CYFRA21-1 is of great significance in the diagnosis and efficacy evaluation of lung cancer.

关 键 词：肺肿瘤 非小细胞肺癌 小细胞肺癌 疗效比较研究 血清学试验 神经元特异性烯醇化酶 细胞角蛋白19片段 

分 类 号：R734.2[医药卫生—肿瘤]