组织中P53、人表皮生长因子受体2表达与乳腺癌患者临床病理特征的关系  

The Relationship between the Expression of P53,Human Epidermal Growth Factor Receptor 2 and Clinicopathological Characteristics in Breast Cancer Patients

作　　者：孙君梅 屈彦平 SUN Jun-mei;QU Yan-ping(Department of Pathology,Yuxi Jianhe Hospital,Nanyang 474500,China)

机构地区：[1]南阳豫西健和医院病理科,南阳474500

出　　处：《四川解剖学杂志》2024年第2期46-48,65,共4页Sichuan Journal of Anatomy

摘　　要：目的:探讨组织中P53、人表皮生长因子受体2(HER2)表达与乳腺癌患者临床病理特征的关系.方法:选取2019年2月至2023年2月于本院采取手术治疗的60例乳腺癌患者作为研究对象.检测其组织中P53、HER2表达,分析其阳性表达与乳腺癌患者不同临床病理特征的相关性.结果:60例乳腺癌患者肿瘤组织中,P53、HER2阳性率分别为53.33%(32/60)和45%(27/60).Ⅲ期、组织低分化、发生淋巴结转移乳腺癌患者的P53、HER2阳性率,显著高于Ⅰ/Ⅱ期、组织中高分化、未发生淋巴结转移者,差异均有统计学意义(P<0.05).乳腺癌患者肿瘤组织中P53、HER2阳性表达,与肿瘤分期、淋巴结转移情况呈正相关关系(r>0,P<0.05),与组织分化程度呈负相关关系(r<0,P<0.05).结论:乳腺癌患者肿瘤组织中P53、HER2多呈阳性表达.肿瘤分期、组织分化程度、淋巴结转移情况,可能与P53、HER2表达有关.Objective:To investigate the relationship between the expression of P53,human epidermal growth factor receptor 2(HER2)and clinicopathological characteristics in breast cancer patients.Methods:A total of 60 breast cancer patients who received surgical treatment in our hospital from February 2019 to February 2023 were selected as the research objects.The expression of P53 and HER2 in cancer tissues of patients was detected,and the correlation between their positive expression and different clinicopathological features was analyzed.Results:The positive expression rates of P53 and HER2 in 60 cases of breast cancer were 53.33%(32/60)and 45%(27/60)respectively.Breast cancer patients with stageⅢ,low histological differentiation,and lymph node metastasis have a higher positive expression rate of P53 and HER2 in cancer tissue than those with stageⅠ/Ⅱ,moderately well histological differentiated and without lymph node metastasis,the differences were statistically significant(P<0.05).The positive expressions of P53 and HER2 in breast cancer tissues were positively correlated with tumor stage and lymph node metastasis(r>0,P<0.05),and negatively correlated with the degree of histological differentiation(r<0,P<0.05).Conclusion:P53 and HER2 are mostly expressed in breast cancer tissues,and their expression may be related to tumor stage,differentiation and metastasis.

关 键 词：乳腺肿瘤 受体 表皮生长因子 基因 p53 肿瘤抑制蛋白质 P53 肿瘤分期 淋巴结转移 组织分化 女(雌)性 

分 类 号：R737.9[医药卫生—肿瘤]