发现驱动中医药研究的新范式  

The Discovery Driven Research Paradigm for Chinese Medicine

作　　者：杨永清[1,2] 尹磊淼 王宇 徐玉东[2] 陈艳焦 Yongqing Yang;Leimiao Yin;Yu Wang;Yudong Xu;Yanjiao Chen(Shanghai Innovation Center of Chinese Medicine Health Service,Shanghai University of Traditional Chinese Medicine,Shanghai 201203;Shanghai Research Institute of Acupuncture and Moribustion,Yueyang Hospital of Integrated Traditional Chinese Medicine and Western Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200030)

机构地区：[1]上海中医药大学上海健康服务协同创新中心,上海201203 [2]上海中医药大学附属岳阳中西医结合医院/上海市针灸经络研究所,上海200030

出　　处：《中国科学基金》2024年第3期412-418,共7页Bulletin of National Natural Science Foundation of China

基　　金：国家自然科学基金项目(82374583,81973951,81574058);上海市中医药三年行动计划[ZY(2021-2023)-0208]的资助。

摘　　要：发挥中医药原创优势、推动我国生命科学实现创新突破是国家需求,但如何挖掘中医药的原创优势,还需要进一步提升思想认知,用现代科学解读中医药学原理。本文在建国以来中医药实证性研究的基础上,正本清源,传承精华,厘清中医学中未加工事实与理性推演之间的关系,发现其中的科学事实;阐幽明微,守正创新,应用现代科学技术,发现中医理论与效应的独特原创优势,从中医出发为医学与生命科学做贡献,解决生物医药“卡脖子”问题两方面,面向未来,列举例证,发现驱动中医药研究的新范式:在厘清古籍医学事实、明确中医药临床效应的基础上,深入研究中国医学中尚不能被现代医学解释的独特生物学现象和过程,以期揭示新的生理现象、阐释新的病理机制、创建新的治疗策略,更加充分地发挥中医药原创优势,推动我国生物医学实现创新突破。It is a national imperative to leverage the inherent advantages of Traditional Chinese Medicine(TCM)and propel China's life sciences towards innovative breakthroughs.However,fully tapping into these advantages and achieving such breakthroughs requires a deeper understanding of the underlying principles.Making it all the more pressing,we should continue to inherit the essence of TCM while pursuing innovations in the field,and interpreting its principles through the lens of modern science.On the basis of the fruitful achievements in the research of TCM since the founding of the People's Republic of China,the paper firstly inherit the essence of discovering the scientific basis of TCM,clarify the relationship between empirical evidence and rational deduction in TCM,and uncover its scientific facts;and secondly tries to elucidate the nuanced and adhere to innovation,apply modern science and technology to identify the unique and original advantages of TCM theory and efficacy,contribute to medicine and life sciences through TCM,promote innovative breakthroughs in life sciences,and address the“bottleneck”in biopharmaceuticals.Looking towards the future and drawing on successful examples,this paper aims to establish a discovery-driven new paradigm for TCM research that will serve Healthy China strategy,enrich the global medical and life science,and ultimately promote the building of a community with a shared health for mankind.

关 键 词：中医药 生命科学 研究范式 靶标发现 

分 类 号：R2-0[医药卫生—中医学]