集束化营养干预对中晚期肝癌TACE术患者营养状况、癌因性疲乏及生活质量的影响  

Effect of cluster nutrition intervention on nutritional status,cancer-related fatigue and quality of life in patients with advanced liver cancer undergoing TACE

作　　者：徐艳[1] 潘立茹[1] XU Yan;PAN Li-ru(Department of Hepatobiliary and Pancreatic Surgery Medicine,the First Medical Center of Chinese PLA General Hospital,Beijing 100020,China)

机构地区：[1]解放军总医院第一医学中心肝胆胰外科医学部,北京100020

出　　处：《川北医学院学报》2024年第8期1148-1152,共5页Journal of North Sichuan Medical College

摘　　要：目的:探讨集束化营养干预对中晚期肝癌经导管肝动脉化疗栓塞(TACE)术患者营养状况、癌因性疲乏及生活质量的影响。方法:选取86例接受TACE治疗的中晚期肝癌患者为研究对象,根据营养干预方式不同分为对照组和观察组,每组各43例。对照组患者予以常规营养干预;观察组患者予以集束化营养干预,干预时间均为3个月。比较两组干预前及干预后营养状态[血红蛋白(Hb)、血清白蛋白(ALB)、前白蛋白(PA)及主观整体营养状况评价表(PG-SGA)评分]、免疫功能[免疫球蛋白A(IgA)、免疫球蛋白M(IgM)、免疫球蛋白G(IgG)]、癌因性疲乏[癌因性疲乏量表(CFS)评分]及生活质量[肝癌患者生活质量量表(QOL-LCV2.0)评分]。结果:干预后,两组患者Hb、ALB、PA均升高(P<0.05),且观察组高于对照组(P<0.05);PG-SGA评分均下降(P<0.05),且观察组低于对照组(P<0.05);IgA、IgM及IgG均升高(P<0.05),且观察组IgM及IgG高于对照组(P<0.05);CFS量表总分及各维度评分均下降(P<0.05),且观察组低于对照组(P<0.05);QOL-LCV2.0量表总分及各维度评分均升高(P<0.05),且观察组高于对照组(P<0.05)。结论:集束化营养干预可改善中晚期肝癌TACE术患者营养状况,提高免疫功能,降低患者癌因性疲乏程度,提升患者生活质量。Objective:To investigate the effect of cluster nutrition intervention on nutritional status,cancer-related fatigue and quality of life in patients with advanced liver cancer undergoing transcatheter arterial chemoembolization(TACE).Methods:86 patients with advanced liver cancer treated with TACE were divided into control group(n=43)and observation group(n=43)according to different nutritional intervention methods.The control group was given routine nutrition intervention,and the observation group was given cluster nutrition intervention.Both groups were intervened for 3 months.The nutritional status[hemoglobin(Hb),serum albumin(ALB),prealbumin(PA,subjective overall nutritional status evaluation table(PG-SGA)],immune function[immunoglobulin A(IgA),immunoglobulin M(IgM),immunoglobulin G(IgG)],cancer-related fatigue[cancer-related fatigue scale(CFS)]and quality of life[quality of life scale for patients with liver cancer(QOL-LCV2.0)]were compared between the two groups before and after intervention.Results:After intervention,Hb,ALB and PA in the two groups increased(P<0.05),and the observation group were higher(P<0.05).The PG-SGA of the two groups decreased(P<0.05),and the observation group was lower(P<0.05).After intervention,IgA,IgM and IgG in the two groups increased(P<0.05),and the observation group s IgM,IgG were higher(P<0.05).After intervention,the total score of CFS scale and the scores of each dimension in the two groups decreased(P<0.05),and the observation group were lower(P<0.05).The total score and each dimension score of QOL-LCV2.0 scale in the two groups increased(P<0.05),and the observation group were higher(P<0.05).Conclusion:Cluster nutrition intervention can improve the nutritional status and immune function of patients with advanced liver cancer undergoing TACE,thereby reducing the degree of cancer-related fatigue and improving the quality of life.

关 键 词：中晚期肝癌 经导管肝动脉化疗栓塞术 集束化护理 营养状况 癌因性疲乏 

分 类 号：R735.7[医药卫生—肿瘤]