长链非编码RNA在脑缺血再灌注损伤炎症反应中研究进展  

Progress of long chain non-coding RNAs in the inflammatory response to cerebral ischemia-reperfusion in⁃jury

作　　者：李蕾[1] 李馨蕊[1] 王颖[1] 李春艳[1] 朱榆红[1] LI Lei;LI Xinrui;WANG Ying;LI Chuyan;ZHU Yuhong(Department of Neurology,The Second Affiliated Hospital of Kunming Medical University,Kunming 650000,China)

机构地区：[1]昆明医科大学第二附属医院神经内科,昆明650032

出　　处：《中国神经精神疾病杂志》2024年第5期305-309,共5页Chinese Journal of Nervous and Mental Diseases

基　　金：国家自然科学基金(编号:82060233);云南省科技厅基础研究项目(编号:202101AT070229);云南省科技厅应用基础计划项目面上项目(编号:202201AT070241);云南省中青年学术和技术带头人后备计划(编号:202305AC160055);昆明医科大学第二附属医院学术带头人(编号:RCTDXS-202301)。

摘　　要：脑缺血再灌注损伤(cerebral ischemia/reperfusion injury,CIRI)是指脑缺血后再恢复血流时导致神经功能缺损症状进一步加重的现象,严重影响患者的预后。近年来研究发现长链非编码RNA(long non-coding RNA,LncRNA)与CIRI后的炎症反应密切相关。从CIRI的机制出发,对近年来发现的影响CIRI炎症反应中LncRNA的表达及其作用机制做一总结,旨在为CIRI的治疗提供新的治疗靶点和研究思路。Inflammatory response is one of the key mechanisms of cerebral ischemia/reperfusion injury(CIRI),which seriously affects the prognosis of patients.In recent years,it has been found that long non-coding RNA(LncRNA)is closely related to the inflammatory response of cerebral ischemia/reperfusion injury,and can affect the development and prognosis of CIRI through multiple pathways.The article reviews and summarizes the LncRNAs and their action pathways affecting the inflammatory response in CIRI.The article preliminary explores the possible mechanisms by which LncRNAs affect CIRI,and also briefly summarizes the drugs related to LncRNA therapy.In order to provide new therapeutic targets and research ideas for the treatment of CIRI.

关 键 词：长链非编码RNA 微小RNA 脑缺血再灌注损伤 炎症反应 

分 类 号：R743[医药卫生—神经病学与精神病学]