小胶质细胞中的脂滴在中枢神经系统疾病中的研究进展  

Research advances in microglial lipid droplet in central nervous system disorders

作　　者：李立琳 胡敬龙(综述) 徐运[1] 张梅娟(审校)[1] LI Lilin;HU Jinglong;XU Yun(Department of Neurology,Nanjing Drum Tower Hospital,Affiliated Hospital of Medical School,Nanjing University,Nanjing 210008,China)

机构地区：[1]南京大学医学院附属鼓楼医院,江苏南京210008

出　　处：《中风与神经疾病杂志》2024年第7期655-660,共6页Journal of Apoplexy and Nervous Diseases

基　　金：国家自然科学基金(81971112);江苏省自然科学基金(BK20191116)。

摘　　要：脂滴曾被简单认为是中性脂质的储存库,但最近的研究表明其在神经胶质细胞的信号转导、代谢和炎症中均发挥重要作用,尤其是在小胶质细胞中。小胶质细胞是中枢神经系统中常驻的单核吞噬细胞,与炎症、吞噬、髓鞘修复,以及衰老过程和神经系统变性疾病密切相关。然而,小胶质细胞内脂滴形成的机制以及对组织病理、相关疾病的影响仍有待阐明。在这篇综述中,我们总结了最近的研究结果,旨在进一步阐明这些问题。Lipid droplet were once simply regarded as depots for neutral lipids,but recent studies have shown that they play an important role in signal transduction,metabolism,and inflammation in glial cells,especially in microglia.Microglia are resident mononuclear phagocytes of the central nervous system and are closely associated with inflammation,phagocytosis,myelin repair,aging,and neurodegenerative diseases.However,further studies are needed to clarify the mechanism of lipid droplet formation in microglia and its influence on histopathology and related diseases.This article summarizes the recent research findings,in order to further clarify these issues.

关 键 词：脂滴 小胶质细胞 脂代谢 中枢神经系统疾病 炎症 

分 类 号：R742[医药卫生—神经病学与精神病学]