解密前列腺癌——从容和科学面对  

Decoding prostate cancer-facing it calmly and rationally

作　　者：寿建忠[1] SHOU Jianzhong(National Cancer Center/Cancer Hospital,Chinese Academy of Medical Sciences,Beijing 100021,China)

机构地区：[1]国家癌症中心/中国医学科学院肿瘤医院,北京100021

出　　处：《癌变．畸变．突变》2024年第4期253-255,260,共4页Carcinogenesis,Teratogenesis & Mutagenesis

摘　　要：前列腺癌是我国男性最为常见的恶性肿瘤之一,发病率逐年升高,其发生发展受年龄、遗传等多种因素影响。前列腺癌早期常无症状,易被忽视,因此开展前列腺癌的健康普教和早期筛查显得尤为重要。血清前列腺特异性抗原是筛查的主要手段,磁共振是前列腺癌诊断和分期的重要方法,而前列腺穿刺活检为确诊的金标准。对患者基于前列腺癌分期和危险因素进行综合施策,实现规范化和精准化治疗,是提高前列腺癌疗效的关键。早期前列腺癌大多通过根治性手术、放疗获得治愈,晚期前列腺癌通过雄激素剥夺治疗联合新颖内分泌药物、化疗、靶向和核素治疗等综合治疗手段,明显改善了患者生存。Prostate cancer(PCa)is one of the most commonly diagnosed malignancy in men,and the incidence of PCa has been increasing in China over the past decade.There are several well-established risk factors for PCa,including age and family history of PCa.There is no specific symptom for PCa at early stage,thus it is of great significance to carry out screening and early detection for PCa.Prostate-specific antigen(PSA)testing is the main approach of screening for PCa,multiparametric MRI plays an important role in PCa diagnosis and staging,and TRUS-guided prostate biopsy is the standard of care.The management of PCa is based on the staging and risk stratification,and treatment strategy should be standardized and precise.Radical prostatectomy or external-beam radiation therapy is the gold standard for localized PCa.For metastatic PCa,treatment approaches with demonstrated survival benefit include androgen deprivation therapy combined with novel hormonal therapy,chemotherapy,targeted therapy,and radionuclide therapy.

关 键 词：前列腺癌 肿瘤筛查 液体活检 精准治疗 

分 类 号：R737.25[医药卫生—肿瘤]