Erbin、δ-catenin在非小细胞肺癌组织中的共表达及其与预后的关系  

The coexpression of Erbin,δ - catenin in non - small cell lung cancer and its relationshipwith prognosis

作　　者：刘帅莹 詹颖婷 李燕玲 于佳乐 韦雪磊[2,3] 张俊毅 LIU Shuaiying;ZHAN Yingting;LI Yanling;YU Jiale;WEI Xuelei;ZHANG Junyi(Baotou Medical College,Inner Mongolia Baotou 014040,China;Department of Pathology,Affliated Hospital of Chifeng University,Inner Mongolia Chifeng 024000,China;Institute of Clinical Pathology,Chifeng University,Inner Mongolia Chifeng 024000,China)

机构地区：[1]包头医学院,内蒙古包头014040 [2]赤峰学院附属医院病理科,内蒙古赤峰024000 [3]赤峰学院临床病理研究所,内蒙古赤峰024000

出　　处：《现代肿瘤医学》2024年第16期3005-3010,共6页Journal of Modern Oncology

基　　金：国家自然科学基金(编号:81860507);内蒙古自治区高校青年科技领军人才支持计划(编号:NJYT-20-A03)。

摘　　要：目的:探讨Erbin、δ-catenin蛋白在非小细胞肺癌(non-small-cell lung carcinoma, NSCLC)组织中的共表达及其与患者预后之间的关系。方法:收集具有随访信息的69例NSCLC标本及20例癌旁正常肺组织标本。采用免疫组织化学方法检测δ-catenin、Erbin在NSCLC组织中的共表达情况,并分析共表达与患者临床病理参数、患者生存时间、预后危险因素之间的相关性。结果:NSCLC组织中δ-catenin和Erbin的阳性表达率均为55.07%(38/69),明显高于正常肺组织(0/20)。Erbin和δ-catenin共表达率为44.93%(31/69),共表达率与肿瘤组织低分化、淋巴结转移、高TNM分期密切相关(P<0.05),且共表达患者的术后生存时间也明显短于非共表达的患者(P<0.05),共表达还是判断NSCLC患者预后的独立危险因素(P<0.05)。结论:Erbin和δ-catenin共表达提示NSCLC患者有着更差的临床预后,两个蛋白联合检测可能具有更重要的预测肿瘤患者预后的临床意义。Objective:To discuss the coexpression ofδ-catenin and Erbin proteins in non-small-cell lung cancer(NSCLC)and its relationship with prognosis.Methods:To collect 69 NSCLC specimens with follow-up information and 20 normal lung tissue specimens adjacent to cancer.Immunohistochemical methods were used to detect the coexpression ofδ-catenin and Erbin in NSCLC tissues,and the correlation between coexpression and clinical pathological parameters,survival time,and prognostic risk factors of patients was analyzed.Results:The positive expression rates ofδ-catenin and Erbin in NSCLC tissue were 55.07%(38/69),significantly higher than those in normal lung tissue(0/20).The coexpression rate of Erbin andδ-catenin was 44.93%(31/69),which was closely related to poor differentiation of tumor tissue,lymph node metastasis,and high TNM staging(P<0.05).The postoperative survival time of coexpression patients was also significantly shorter than that of non coexpression patients(P<0.05).Coexpression was also an independent risk factor for predicting the prognosis of NSCLC patients(P<0.05).Conclusion:The coexpression of Erbin andδ-catenin suggests that NSCLC patients have a poorer clinical prognosis,and the combined detection of the two proteins may have more important clinical significance in predicting the prognosis of tumor patients.

关 键 词：ERBIN δ-catenin 非小细胞肺癌 预后 

分 类 号：R734.2[医药卫生—肿瘤]