线粒体二羧酸盐载体SLC25A10:肿瘤防治的新靶点  

Mitochondrial dicarboxylate carrier SLC25A10: New targets for the preventionand treatment of tumors

作　　者：方玉 周艺涵 张青春 丁伟峰[1] 张健锋 FANG Yu;ZHOU Yihan;ZHANG Qingchun;DING Weifeng;ZHANG Jianfeng(School of Public Health,Nantong University,Jiangsu Nantong 226001,China)

机构地区：[1]南通大学公共卫生学院,江苏南通226001

出　　处：《现代肿瘤医学》2024年第16期3138-3144,共7页Journal of Modern Oncology

基　　金：国家自然科学基金资助项目(编号:81974313);江苏省南通市科技局基金资助项目(编号:JC22022040)。

摘　　要：细胞代谢失调对维持癌细胞的恶性增殖至关重要,线粒体内膜中的溶质载体25(SLC25)核编码转运体家族深度参与细胞代谢,SLC25A10在多种实体肿瘤中高表达,这可能是一种新的肿瘤防治的靶点。该文将总结线粒体SLC25A10载体的相关作用,并将对其在肿瘤中的进展及癌细胞代谢中的影响作一综述。The dysregulation of cellular metabolism is crucial for sustaining the malignant proliferation of cancer cells.The solute carrier 25(SLC25)nuclear-encoded transporter family within the mitochondrial inner membrane plays a profound role in cellular metabolism.SLC25A10 is highly expressed in various solid tumors,potentially serving as a novel target for cancer prevention and treatment.This article will summarize the relevant functions of mitochondrial SLC25A10 carriers and provide an overview of their progress in tumors,as well as their impact on cancer cell metabolism.

关 键 词：SLC25A10 谷胱甘肽 肝癌 人骨肉瘤 肺癌 

分 类 号：R730.5[医药卫生—肿瘤]