TACAN参与正畸机械性疼痛调控的研究进展  

Research progress of TACAN's involvement in orthodontic mechanical pain modulation

作　　者：徐思艺 杨振泽 薛蕾蕾 齐叶子 林军[1] XU Siyi;YANG Zhenze;XUE Leilei;QI Yezi;LIN Jun(Orthodontics Department,the First Affiliated Hospital of Zhejiang University School of Medicine,Hangzhou 310000,China)

机构地区：[1]浙江大学医学院附属第一医院口腔正畸科,浙江杭州310000

出　　处：《口腔医学》2024年第7期540-544,共5页Stomatology

基　　金：国家自然科学基金(81970978)。

摘　　要：正畸治疗主要通过对颌骨以及牙齿施加机械力来改善口腔功能,达到治疗目标。而口腔疼痛则是患者诊疗过程中最常见的症状,它通常由持续施加的正畸机械力引起,但其机制尚未完全明确,是临床上的重要难题。而近年来研究发现了一种蛋白—TACAN,在疼痛发生发展的过程中起到关键的调控作用,有望成为未来治疗机械性疼痛的治疗靶点。由于对TACAN的研究尚不明确,其具体机制还有待进一步阐明和验证,所以本文系统回顾了TACAN参与机械性疼痛调控的研究进展,梳理了TACAN发挥的具体功能,为TACAN的进一步研究提供新的思路。Orthodontic treatment mainly improves oral function and achieves treatment goals by applying mechanical force to the jawbone and teeth.However,oral pain is the most common symptom experienced by patients during the diagnosis and treatment process.It is usually caused by sustained application of orthodontic mechanical force,but its mechanism is not fully understood,posing a significant clinical challenge.In recent years,a protein called TACAN has been discovered to play a crucial regulatory role in the occurrence and development of pain,offering a potential therapeutic target for addressing mechanical pain in the future.Since research on TACAN is still unclear,its specific mechanism requires further elucidation and verification.This article systematically reviews the research progress of TACAN's involvement in the modulation of mechanical pain,summarizes the specific functions of TACAN,and provides new perspectives for further research on TACAN.

关 键 词：TACAN 口腔机械性疼痛 离子通道 

分 类 号：R783.5[医药卫生—口腔医学]