SKA2:一种通用的肿瘤生物标志物和潜在的治疗靶点  

Spindle and KT associated 2(SKA2):A universal tumour biomarker and a potential therapeutical target

作　　者：岑美芝 高陆 任明强 CEN Meizhi;GAO Lu;REN Mingqiang(Department of Hematology,Affiliated Hospital of Zunyi Medical University,Guizhou Zunyi 563000,China.)

机构地区：[1]遵义医科大学附属医院血液内科,贵州遵义563000

出　　处：《现代肿瘤医学》2024年第14期2641-2646,共6页Journal of Modern Oncology

基　　金：贵州省卫健委联合基金(编号:gzwkj2022-069)。

摘　　要：SKA2基因是SKA复合体的成员,对有丝分裂中期赤道板的维持以及纺锤体检测点的适时关闭至关重要。它参与细胞周期的调控,并通过糖皮质激素受体、p53等途径影响细胞的增殖和凋亡,与肿瘤密切相关。研究表明,SKA2是一种癌基因,在多种恶性肿瘤中显示高表达,促进肿瘤的发生、发展。该文重点综述SKA2在各种癌症中的调控、生物学功能和临床重要性。SKA2 protein is a part of the spindle and kinetochore associated(SKA)complex,which plays a critical role in the maintenance of the metaphase plate and spindle checkpoint silencing during mitosis.It is involved in the regulation of cell cycle,and affects cell proliferation and apoptosis by glucocorticoid receptor,p53 and other pathways,which is closely associated with tumorigenesis.Studies have shown that SKA2 is an oncogene that is highly expressed in a variety of malignant tumors and promotes the occurrence and development of tumors.This review focuses on discussing the regulation,biological functions and clinical importance of SKA2 in human cancers.

关 键 词：SKA2 SKA复合体 肿瘤 

分 类 号：R730[医药卫生—肿瘤]