线粒体-内质网结构偶联(MAMs)在阿尔茨海默病发病机制中的研究进展  

Research progress on the role of mitochondria⁃associated membranes in the pathogenesis of Alzheimer’s disease

作　　者：刘诗雨 许玉珉 徐红彩 路芳梅 LIU Shiyu;XU Yumin;XU Hongcai;LU Fangmei(Department of Encephalopathy,the First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,China;Henan University of Chinese Medicine,the First Clinical Medical College,Zhengzhou 450000)

机构地区：[1]河南中医药大学第一附属医院脑病科,郑州450000 [2]河南中医药大学第一临床医学院,郑州450000

出　　处：《中国比较医学杂志》2024年第7期121-130,共10页Chinese Journal of Comparative Medicine

基　　金：国家自然科学基金(81904265);河南省科技攻关项目(242102311255);河南省博士后基金项目(HN2022083);河南省医学科技攻关计划省部共建重点项目(SBGJ202302101);2023年度河南省卫生健康委员会国家中医药传承创新中心科研专项(2023ZXZX1004)。

摘　　要：线粒体-内质网结构偶联(mitochondria⁃associated membranes,MAMs)是线粒体外膜和内质网膜之间进行通讯交流及物质交换的特殊结构域,执行不同条件下细胞生命活动的多种生物学过程。MAMs功能障碍介导的Ca2+稳态失衡、内质网应激、线粒体自噬缺陷、线粒体分裂-融合平衡障碍、脂质代谢紊乱、炎症反应是阿尔茨海默病(Alzheimer’s disease,AD)关键的发病机制。本文围绕MAMs结构与功能、参与AD病理环节、药物干预靶点等方面进行综述,探讨MAMs在AD发病中的作用及最新机制研究进展,以期为AD的防治提供新思路。Mitochondria⁃associated membranes(MAMs)are a subcellular compartment involved in the communication and material exchange between the mitochondrial outer membrane and endoplasmic reticulum membrane.MAMs perform various biological processes in cells under different conditions.MAM⁃dysfunction⁃mediated calcium homeostasis imbalance,endoplasmic reticulum stress,mitophagy defects,mitochondrial fission/fusion dynamics imbalance,lipid metabolism disorders,and inflammatory responses are key pathogenic factors in Alzheimer’s disease(AD).This article reviews the structure and function of MAMs,their involvement in AD pathology,and drug intervention targets,and discusses the role of MAMs in the pathogenesis of AD and the latest research into their mechanisms,to provide new ideas for the prevention and treatment of AD.

关 键 词：阿尔茨海默病 线粒体-内质网结构偶联 钙稳态 内质网应激 线粒体自噬 线粒体分裂-融合动力学 脂质代谢 炎症 

分 类 号：R-33[医药卫生]