Ezrin蛋白在幽门螺杆菌感染的结节性胃炎中的研究进展  

Effects of ezrin protein on Helicobacter pylori⁃induced nodular gastritis

作　　者：王朋[1,2] 朱宏伟 姜树原 刘晓蕾 高冰 邵国 WANG Peng;ZHU Hongwei;JIANG Shuyuan;LIU Xiaolei;GAO Bing;SHAO Guo(Department of Medical Laboratory,the Second Affiliated Hospital of Baotou Medical College,Baotou 104030,China;Department of Public Health,International College,Krirk University,Bangkok 10220,Thailand;Center for Translational Medicine,the Third People’s Hospital of Longgang District,Shenzhen 518100;Inner Mongolia Key Laboratory of Hypoxic Translational Medicine,Baotou Medical College,Baotou 014060)

机构地区：[1]包头医学院第二附属医院医学检验科,内蒙古包头014030 [2]格乐大学国际学院公共卫生系,泰国曼谷10220 [3]深圳市龙岗区第三人民医院转化医学中心,深圳518100 [4]内蒙古低氧转化医学重点实验室,包头医学院,内蒙古包头014060

出　　处：《中国比较医学杂志》2024年第7期150-156,共7页Chinese Journal of Comparative Medicine

基　　金：国家自然科学基金(82060337);深圳市龙岗区医疗卫生科技计划项目(LGKCYLWS2021000033,LGKCYLWS2023025);深圳市科技计划计划项目基础研究面上项目(JCYJ20220531092412028,JCYJ20230807121306012);包头医学院临床医学+X多学科联合科研基金(BYJJ⁃DXK 2022047);包头医学院科学研究基金(BYJJ⁃QWB 202212)。

摘　　要：ERM蛋白家族(包括ezrin、radixin、moesin)在细胞形态、迁移和信号转导中发挥着至关重要的作用。Ezrin是ERM蛋白家族的成员之一,是幽门螺杆菌(Helicobacter pylori)感染宿主所致细胞毒性的重要介质,通过ezrin磷酸化可以调节其与肌动蛋白细胞骨架的相互作用,进而对细胞形态产生显著影响。本文综述了ezrin蛋白在H.pylori感染引发的结节性胃炎中的重要性,探讨了ezrin蛋白的结构及其功能、信号通路及磷酸化与结节性胃炎的关系,为以ezrin蛋白作为潜在的治疗靶点对结节性胃炎的防治提供新思路。The ezrin,radixin,moesin(ERM)protein family plays a pivotal role in cell morphology,migration,and signal transduction.Ezrin,as a prominent member of this family,is highly involved in these processes.Ezrin phosphorylation is particularly crucial,by regulating the interaction between ezrin and the actin cytoskeleton.This interaction is a key mediator of cytotoxicity in host cells infected with Helicobacter pylori,significantly impacting cell morphology.In this review,we comprehensively summarize the multifaceted role of ezrin protein in H.pylori⁃induced nodular gastritis.We consider the relationships between ezrin’s structure,function,signaling pathways,and phosphorylation in the context of nodular gastritis.Moreover,this review highlights the role of ezrin protein as a potential therapeutic target,offering novel insights for the prevention and treatment of nodular gastritis.

关 键 词：幽门螺杆菌 结节性胃炎 ERM蛋白 EZRIN 

分 类 号：R-33[医药卫生]