Chinese Medicine Combined with Adjuvant Chemotherapy for Improving Myelosuppression in Colorectal Cancer Patients:A Systematic Review and Network Meta-Analysis  

作　　者：LI Rui ZHANG Tong YAN Shao-hua YAN Yun-zi DING Ya-cong WANG Yan-song YANG Yu-fei 

机构地区：[1]Department of Oncology,China Academy of Chinese Medical Sciences,Xiyuan Hospital,Beijing,100091,China [2]Department of Oncology,Dongfang Hospital Beijing University of Chinese Medicine,Beijing,100078,China [3]Graduate School,Beijing University of Chinese Medicine,Beijing,100029,China

出　　处：《Chinese Journal of Integrative Medicine》2024年第7期643-652,共10页中国结合医学杂志（英文版）

基　　金：Supported by Project of Qihuang Scholar(No.010120006);the National Natural Science Foundation of China(No.82174461);the Capital Health Development Scientific Research Project(No.2022-1-41-71)。

摘　　要：Objective To assess the effectiveness of Chinese herbal medicine(CHM)combined with adjuvant chemotherapy on myelosuppression for colorectal cancer(CRC)patients using network meta-analysis(NMA).Methods Literature searches in both international(PubMed,Embase,Web of Science,and Cochrane Library)and Chinese(China Science and Technology Journal Database,Wanfang Data,China National Knowledge Infrastructure)databases for relevant randomized controlled trials(RCTs)were conducted from inception until October 10,2022.We included RCTs of patients who received CHM combined with chemotherapy,including FOLFOX,XELOX,FOLFIRI,and other relevant regimens in the CHM treatment group.The outcomes included the incidence of myelosuppression,leukopenia,hemoglobin reduction,and thrombocytopenia.Two reviewers independently screened the databases,extracted the data,and assessed the risk of bias and credibility of evidence.RevMan 5.4.1 software and STATA 14.0 were used to perform the NMA.Results A total of 31 RCTs were included,published from 2008 to 2021 in Chinese.Among these,2,314 participants comparing the following 9 CHMs were identified:Shengbai Recipe(SBR),Bazhen Decoction(BZD),Jianpi Jiedu Recipe(JJR),Jianpi Recipe(JR),Compound Cantharis Capsule(CCC),Zaofan Pill(ZFP),Guilu Erxian Gel(GL),Buzhong Tiaogan Decoction(BZ),and Qiamagu Capsule(QM).The results of NMA found an indirect comparison.Based on the surface under the cumulative ranking curve(SUCRA),the ZFP+chemotherapy group had the lowest incidence of myelosuppression,with an odds ratio(OR)of 0.08[95%confidence interval(CI):0.01,0.76],whereas the GL+chemotherapy group had the lowest incidence of leukopenia,hemoglobin reduction,and thrombocytopenia,with an OR of 5.25(95%CI:2.41,11.43),4.66(95%CI:2.23,9.72),and 0.27(95%CI:0.13,0.54),respectively.Moreover,BZD+chemotherapy could alleviate leukopenia,hemoglobin reduction,and thrombocytopenia(P<0.01).Pairwise comparison showed that there was no difference in the efficacy among the 8 CHMs+chemotherapy group.The comparison and adjustment

关 键 词：Chinese herbal medicine colorectal cancer network meta-analysis systematic review MYELOSUPPRESSION CHEMOTHERAPY 

分 类 号：R735.34[医药卫生—肿瘤]