Changes of the peripapillary vascular parameters inpremature infants without retinopathy of prematurityusing U-net segmentation  

作　　者：Shuai Liu Lei Liu Cui-Xia Ma Liu-Hui Huang Bin Li 

机构地区：[1]School of Information Science and Technology,University of Science and Technology of China,Hefei 230022,Anhui Province,China [2]Zhejiang Lab,Hangzhou 311121,Zhejiang Province,China [3]Eye Institute,Affiliated Hospital of Nantong University,Medical School of Nantong University,Nantong 226006,Jiangsu Province,China [4]Anhui Province Maternity and Child Health Hospital,Maternity and Child Health Hospital Affiliated to Anhui Medical University,Hefei 230001,Anhui Province,China [5]Department of Ophthalmology,Tenth People’s Hospital Affiliated with Shanghai Tongji University School of Medicine,Shanghai 200072,China

出　　处：《International Journal of Ophthalmology(English edition)》2024年第8期1453-1461,共9页国际眼科杂志（英文版）

基　　金：Supported by the Fundamental Research Funds for the Central Universities (No.WK2100000045);the National Natural Science Foundation of China (No.U19B2044);Hefei Health Care Commission 2022 Applied Medical Research Project (No.Hwk2022yb028);Zhejiang Lab Open Research Project (No.K2022QA0AB04).

摘　　要：AIM:To quantitatively assess the changes in mean vascular tortuosity(mVT)and mean vascular width(mVW)around the optic disc and their correlation with gestational age(GA)and birth weight(BW)in premature infants without retinopathy of prematurity(ROP).METHODS:A single-center retrospective study included a total of 133(133 eyes)premature infants[mean corrected gestational age(CGA)43.6wk]without ROP as the premature group and 130(130 eyes)CGA-matched fullterm infants as the control group.The peripapillary mVT and mVW were quantitatively measured using computerassisted techniques.RESULTS:Premature infants had significantly higher mVT(P=0.0032)and lower mVW(P=0.0086)by 2.68(10^(4) cm^(-3))and 1.85μm,respectively.Subgroup analysis with GA showed significant differences(P=0.0244)in mVT between the early preterm and middle to late preterm groups,but the differences between mVW were not significant(P=0.6652).The results of the multiple linear regression model showed a significant negative correlation between GA and BW with mVT after adjusting sex and CGA(P=0.0211 and P=0.0006,respectively).For each day increase in GA at birth,mVT decreased by 0.1281(10^(4) cm^(-3))and for each 1 g increase in BW,mVT decreased by 0.006(10^(4) cm^(-3)).However,GA(P=0.9402)and BW(P=0.7275)were not significantly correlated with mVW.CONCLUSION:Preterm birth significantly affects the peripapillary vascular parameters that indicate higher mVT and narrower mVW in premature infants without ROP.Alterations in these parameters may provide new insights into the pathogenesis of ocular vascular disease.

关 键 词：premature infants retinopathy of prematurity retinal vessels parameter computer-assisted techniques 

分 类 号：R774.1[医药卫生—眼科]