中国西部某三甲医院藏族与汉族唇腭裂患者ABO血型及Rh血型分布研究  

Distribution of ABO and Rh Blood Groups in Tibetan and Han Populations With Cleft Lip and Palate in a Tertiary Hospital in Western China

作　　者：段世均[1] 郑谦[1] 石冰[1] 冯帆 DUAN Shijun;ZHENG Qian;SHI Bing;FENG Fan(State Key Laboratory of Oral Diseases,National Center for Stomatology,National Clinical Research Center for Oral Diseases,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China;Department of Human Resources,Chengdu Medical College,Chengdu 610041,China)

机构地区：[1]口腔疾病防治全国重点实验室国家口腔医学中心国家口腔疾病临床医学研究中心四川大学华西口腔医院,成都610041 [2]成都医学院人事处,成都610041

出　　处：《四川大学学报（医学版）》2024年第4期932-938,共7页Journal of Sichuan University(Medical Sciences)

基　　金：国家重点研发计划(No.2016YFC0905203)资助。

摘　　要：目的 研究中国西部藏族与汉族唇腭裂患者ABO血型和Rh血型分布的关系。方法 统计2016年1月–2023年9月就诊于四川大学华西口腔医院的藏族及汉族先天性唇腭裂患者的A、B、O、AB血型及Rh血型,与正常人群的A、B、O、AB血型及Rh血型进行比较。分别统计A、B、O、AB血型患者中单纯唇裂、单纯腭裂及唇裂伴腭裂表型发病人数,采用卡方检验进行统计学分析。结果 共收集藏族唇腭裂患者1 227例,汉族唇腭裂患者4 064例,对照组人群5 360例。藏族唇腭裂患者ABO血型分布特征为O>B>A>AB,Rh阳性血型为100%,O型占41.15%,B型占30.64%,汉族唇腭裂患者ABO血型分布特征为O>A>B>AB,Rh阳性血型为99.58%,O型占35.78%,A型占30.54%,藏、汉族唇腭裂患者之间ABO血型表现出明显差异(P<0.005),Rh血型无明显差异;藏族唇腭裂患者与对照组人群ABO血型分布显示出明显的差异,而汉族唇腭裂患者与对照组人群ABO血型分布并未显示出明显的差异;在对亚型的分析中发现,藏族患者单纯唇裂、单纯腭裂以及唇裂伴腭裂各亚型血型分布均为O>B>A>AB,汉族唇腭裂患者各亚型血型分布均为O>A>B>AB,单纯唇裂及唇裂伴腭裂亚型中藏族与汉族血型分布存在差异(P<0.001),而在腭裂亚型分组中血型分布无差异;藏族唇裂患者中O型血的比例明显高于汉族唇腭裂患者。四川省、西藏自治区及青海省藏族唇腭裂患者血型分布均为O>B>A>AB,其中甘孜州石渠县、白玉县及昌都市察雅县以B型血为主,其余均以O型血为主。结论 中国西部藏族与汉族唇腭裂患者ABO血型分布均表现出明显差异,唇腭裂患者中O型血的分布高于正常人群,且在不同表型中均表现出同样的趋势,但仅在单纯唇裂与唇裂伴腭裂表型中表现出藏族与汉族间ABO血型分布的差异,O型血藏族唇腭裂患者较汉族患者更容易出现唇裂畸形。Objective Congenital cleft lip and palate is a common birth defect that seriously affects the lives of the afflicted children and their families.Previously,no research has been done to investigate the pathogenic characteristics of cleft lip and palate among ethnic minorities,for example,Tibetans,a minority ethnic group with a large population in China.This study aims to investigate the relationship between the occurrence of cleft lip and palate in Tibetans and Han Chinese in western China and the distribution of ABO blood groups and Rh blood groups to provide a theoretical basis for the precise prevention and treatment of cleft lip and palate.Methods In this study,statistics on Tibetan patients with cleft lip and palate,some Han patients with cleft lip and palate,and normal controls from western China were retrospectively collected.All participants were patients from West China Stomatology Hospital,Sichuan University.All patients with cleft lip and palate received treatment at the hospital between January 2016 and September 2023.The normal controls were outpatients or inpatients who did not have cleft lip and palate,and who received treatment at the hospital between January 2020 and October 2023.Information on the A,B,O,and AB blood groups and Rh positive and negative blood groups of the patients was collected and compared with that of the normal controls.The incidence of different phenotypes,including cleft lip alone,cleft palate alone,and cleft lip with cleft palate,in patients of blood groups A,B,O and AB were statistically analyzed by Chi-square test.Results A total of 1227 Tibetan patients with cleft lip and palate,4064 Han patients with cleft lip and palate,and 5360 normal controls were included in the study.Among all the patients with cleft lip and palate,1863 had cleft lip alone,1425 had cleft palate alone,and 2003 had cleft lip with cleft palate.The ABO blood group distribution of Tibetan patients with cleft lip and palate was characterized as O>B>A>AB,with Rh positive blood group accounting for 100%,blo

关 键 词：唇裂 腭裂 藏族 ABO血型系统 RH血型系统 

分 类 号：R782.2[医药卫生—口腔医学]