还少丹辅助康复训练治疗血管性痴呆伴H型高血压的疗效  

Effect of Huanshaodan Assisted Rehabilitation Training on Vascular Dementia with H-type Hypertension

作　　者：申法涛 赵彦青[2] 刘爱华[2] 王松龄[3] SHEN Fatao;ZHAO Yanqing;LIU Aihua;WANG Songling(Department of Neurology,Yangcheng Hospital,Zhengzhou 452470,Henan,China;Senior Cadre Ward of Henan Provincial Hospital of Traditional Chinese Medicine,Zhengzhou 450000,Henan,China;Department of Encephalopathy,Henan Provincial Hospital of Traditional Chinese Medicine,Zhengzhou 450000,Henan,China)

机构地区：[1]郑州市阳城医院神经内科,河南郑州452470 [2]河南省中医院老干部病房,河南郑州450000 [3]河南省中医院脑病科,河南郑州450000

出　　处：《中国药物滥用防治杂志》2024年第6期1126-1129,1156,共5页Chinese Journal of Drug Abuse Prevention and Treatment

摘　　要：目的:研究还少丹辅助康复训练治疗血管性痴呆(VD)伴H型高血压的疗效及对其炎性因子、认知功能的影响。方法:以2021年1月—2022年2月郑州市阳城医院收治的150例VD伴H型高血压患者为研究对象,采用随机数字表法分为对照组(75例)和还少丹组(75例)。对照组采用常规药物治疗+康复训练,还少丹组采用还少丹+常规药物治疗+康复训练。比较两组临床疗效、精神状态量表(MMSE)、改良Barthel指数(MBI)、蒙特利尔认知评估量表(Mo CA)评分、动态血压[24 h收缩压变异系数(24 hSBPCV)、24 h舒张压变异系数(24 hDBPCV)]、血管内皮功能指标[一氧化氮(NO)、血管内皮生长因子(VEGF)、内皮素(ET-1)]、血清同型半胱氨酸(Hcy)和炎性因子[超敏C反应蛋白(hs-CRP)、肿瘤坏死因子(TNF-α)、白细胞介素-1β(IL-1β)]水平。结果:还少丹组临床总有效率(89.33%)高于对照组(74.67%)(P<0.05);还少丹组MMSE、MBI、Mo CA评分高于对照组(P<0.05);还少丹组24 hSBPCV、24 hDBPCV低于对照组(P<0.05);还少丹组血清ET-1水平低于对照组,血清VEGF、NO水平高于对照组(P<0.05);还少丹组血清Hcy、hs-CRP、TNF-α、IL-1β水平低于对照组(P<0.05)。结论:采用还少丹辅助康复训练联合依那普利治疗VD伴H型高血压患者能显著提高临床疗效,增强患者血管内皮功能、智力状态、认知功能、日常生活能力,抑制炎症反应,降低血压。Objective:To study the effect of Huanshaodan assisted rehabilitation training on vascular dementia(VD)with H-type hypertension and its effect on inflammatory factors and cognitive function.Methods:A total of 150 patients with VD and H-type hypertension admitted to our hospital from January 2021 to February 2022 were enrolled in the study.They were divided into control group(75 patients)and Huanshaodan group(75 patients)by random number table method.The control group was treated with conventional drug therapy+rehabilitation training,and the Huanshaodan group was treated with Huanshaodan+conventional drug therapy+rehabilitation training.The clinical efficacy,mental state scale(MMSE),modified Barthel index(MBI),Montreal Cognitive Assessment Scale(MoCA)score,ambulatory blood pressure[24 h systolic blood pressure coefficient of variation(24 hSBPCV)],24 h diastolic blood pressure coeficient of variation(24 hDBPCV),vascular endothelial function indexes[nitric oxide(NO),vascular endothelial growth factor(VEGF),endothelin(ET-1)],serum homocysteine(Hcy)and inflammatory factors[high-sensitivity C-reactive protein(hs-CRP),tumor necrosis factor(TNF-α),interleukin-1β(IL-1β)]were compared between the two groups.Results:The total effective rate of the treatment group was 89.33%,which was higher than 74.67% of the control group(P<0.05).The scores of MMSE,MBI and MoCA in the treatment group were higher than those in the control group(P<0.05).The 24 hSBPCV and 24 hDBPCV in Huanshaodan group were lower than those in control group(P<0.05).The level of serum ET-1 in Huanshaodan group was lower than that in control group,and the levels of serum VEGF and NO were higher than those in control group(P<0.05).The levels of serum Hcy,hs-CRP,TNF-α and IL-1β in the treatment group were lower than those in the control group(P<0.05).Conclusion:Huanshaodan assisted rehabilitation training combined with enalapril in the treatment of VD patients with H-type hypertension can significantly improve the clinical efficacy,enhance the vascular endoth

关 键 词：还少丹 康复训练 血管性痴 H型高血压 认知功能 

分 类 号：R749.13[医药卫生—神经病学与精神病学] R544.1[医药卫生—临床医学]