结肠镜息肉切除术联合地衣芽孢杆菌活菌对结肠息肉患者的临床效果及对肠道菌群、预后的影响  

Clinical Effect of Colonoscopic Polypectomy Combined with Bacillus Licheniformis on Patients with Colonic Polyps and its Effect on Intestinal Flora and Prognosis

作　　者：叶利君 谢建生 洪艳芬 YE Li-jun;XIE Jian-sheng;HONG Yan-fen(Department of Gastroenterology,Wuyuan County People's Hospital,Wuyuan 333200,Jiangxi,China;Department of Pharmacy,Wuyuan County People's Hospital,Wuyuan 333200,Jiangxi,China)

机构地区：[1]婺源县人民医院消化内科,江西婺源333200 [2]婺源县人民医院药剂科,江西婺源333200

出　　处：《医学信息》2024年第15期79-82,共4页Journal of Medical Information

基　　金：上饶市科技计划医疗卫生指导性项目(编号:2023CZDX15)。

摘　　要：目的研究地衣芽孢杆菌活菌胶囊在结肠镜下高频电凝电切术患者中的临床效果及对肠道菌群、预后的影响。方法选取2021年1月-2022年12月于我院治疗的80例结肠息肉术后患者为研究对象,采用随机数字表法分为对照组(n=40)和观察组(n=40),对照组采用结肠镜下高频电凝电切术治疗,观察组在对照组基础上给予地衣芽孢杆菌活菌胶囊治疗,比较两组临床效果、肠道菌群、并发症发生率、6个月后复发率及生活质量水平。结果观察组治疗总有效率为95.00%,高于对照组的82.50%(P<0.05);两组治疗后双歧杆菌、乳杆菌计数高于治疗前,大肠杆菌低于治疗前,且观察组双歧杆菌、乳酸菌计数高于对照组,大肠杆菌计数低于对照组(P<0.05);观察组并发症发生率为12.50%,低于对照组的27.50%(P<0.05);随访6个月,观察组复发率为5.00%,低于对照组的17.50%(P<0.05);两组治疗后生活质量各维度评分均高于治疗前,且观察组高于对照组(P<0.05)。结论地衣芽孢杆菌活菌胶囊在结肠镜下高频电凝电切术患者中具有较高的临床效果,可促进肠道菌群恢复,降低并发症发生率及复发率,提高患者生活质量水平,值得临床加以应用。Objective To study the clinical effect of bacillus licheniformis capsule on patients undergoing high-frequency electrocoagulation resection under colonoscopy and its effect on intestinal flora and prognosis.Methods A total of 80 patients with colon polyps treated in our hospital from January 2021 to December 2022 were selected as the research objects.They were divided into control group(n=40)and observation group(n=40)by random number table method.The control group was treated with high-frequency electrocoagulation resection under colonoscopy.The observation group was treated with Bacillus licheniformis capsule on the basis of the control group.The clinical effect,intestinal flora,complication rate,recurrence rate after 6 months and quality of life were compared between the two groups.Results The total effective rate of treatment in the observation group was 95.00%,which was higher than 82.50%in the control group(P<0.05).After treatment,the counts of Bifidobacterium and Lactobacillus in the two groups were higher than those before treatment,and the count of Escherichia coli was lower than thatbefore treatment,while the counts of Bifidobacterium and Lactobacillus in the observation group were higher than those in the control group,and the count of Escherichia coli was lower than that in the control group(P<0.05).The incidence of complications in the observation group was 12.50%,which was lower than 27.50%in the control group(P<0.05).After 6 months of follow-up,the recurrence rate of the observation group was 5.00%,which was lower than 17.50%of the control group(P<0.05).The scores of each dimension of quality of life in the two groups after treatment were higher than those before treatment,and those in the observation group were higher than those in the control group(P<0.05).Conclusion Bacillus licheniformis capsule has a high clinical effect in patients undergoing high-frequency electrocoagulation resection under colonoscopy,which can promote the recovery of intestinal flora,reduce the incidence of complications a

关 键 词：地衣芽孢杆菌活菌胶囊 结肠息肉 结肠镜下高频电凝电切术 肠道菌群 

分 类 号：R735.35[医药卫生—肿瘤]