HN1L、PLK1在食管胃交界腺癌中的表达及与肿瘤进展和患者预后的关系研究  

Relationship between the expressions of HN1L and PLK1 in patients with adenocarcinoma of the esophagogastric junction and tumor progression and prognosis

作　　者：魏娉[1] 姜琳娜[1] 安欣[1] 何鹏 李香红 WEI Ping;JIANG Linna;AN Xin;HE Peng;LI Xianghong(Department of Pathology,Handan First Hospital,Handan 056002,China)

机构地区：[1]邯郸市第一医院病理科,056002

出　　处：《浙江医学》2024年第14期1469-1473,I0003,共6页Zhejiang Medical Journal

基　　金：河北省医学科学研究重点课题计划(20181641)。

摘　　要：目的探讨血液和神经表达1样蛋白(HN1L)、Polo样激酶1蛋白(PLK1)在食管胃交界腺癌(AEGJ)中的表达及其与肿瘤进展和患者预后的关系。方法回顾性收集2017年6月至2020年6月邯郸市第一医院手术切除的105例AEGJ组织及其距离肿瘤边缘5 cm处的癌旁组织。采用免疫组化法观察并比较癌组织和癌旁组织HN1L、PLK1表达评分,比较不同临床特征AEGJ患者癌组织HN1L、PLK1表达评分,采用Pearson相关分析两种蛋白表达评分的相关性,根据表达评分分组,生存分析采用Kaplan-Meier生存曲线,预后分析采用多因素Cox回归分析。结果癌组织中HN1L、PLK1表达评分均显著高于癌旁组织(均P<0.05)。相比于肿瘤-淋巴结-远处转移(TNM)分期Ⅰ~Ⅱ期、无淋巴结转移AEGJ患者,TNM分期Ⅲ~Ⅳ期、有淋巴结转移AEGJ患者癌组织HN1L、PLK1表达评分显著升高(均P<0.05)。癌组织HN1L表达评分与PLK1表达评分呈正相关(P<0.01)。AEGJ患者3年总生存率为43.8%。生存分析显示,HN1L高表达组患者和PLK1高表达组患者3年总生存率均显著低于HN1L低表达组和PLK1低表达组(均P<0.01)。多因素Cox回归分析显示,淋巴结转移、TNM分期Ⅲ~Ⅳ期、HN1L和PLK1高表达是影响AEGJ患者预后的独立危险因素(均P<0.01)。结论AEGJ患者癌组织HN1L、PLK1表达与肿瘤恶性程度有关,可作为预测患者预后的潜在指标。Objective To explore the relationship between the expressions of hematological and neurological expressed 1-like(HN1L)and Polo like kinase 1(PLK1)in patients with adenocarcinoma of the esophagogastric junction(AEGJ)and tumor progression and prognosis.Methods The AEGJ tissue of 105 cases surgically removed in Handan First Hospital from June 2017 to June 2020 and the adjacent tissue 5 cm away from the tumor margin were collected.The expression scores of HN1L and PLK1 in cancer tissues and adjacent tissues were compared to analyze the relationship between HN1L and PLK1 expression levels and clinical features.Correlation analysis of the expressions of two proteins was performed using Pearson correlation,while survival and prognostic analyses were conducted using Kaplan-Meier survival curve and multivariate Cox regression,respectively.Results The expression scores of HN1L and PLK1 in cancer tissues of AEGJ patients were significantly higher than those of adjacent tissues(both P<0.05).Compared with AEGJ patients with tumor-node-metastasis(TNM)stagesⅠ-Ⅱand no lymph node metastasis,the expression scores of HN1L and PLK1 in cancer tissues of AEGJ patients with TNM stagesⅢ-Ⅳand lymph node metastasis were significantly higher(all P<0.05).

关 键 词：血液和神经表达1样蛋白 Polo样激酶1蛋白 食管胃交界腺癌 肿瘤进展 预后 

分 类 号：R735.2[医药卫生—肿瘤]