载体介导的狂犬病蛋白疫苗的研制现状  

Research status of vector-based rabies protein vaccine

作　　者：李文桂[1] 陈雅棠[1] Li Wengui;Chen Yatang(Unit of Parasitic Diseases,Institute of Infectious and Parasitic Diseases,the First Affiliated Hospital,Chongqing Medical University,Chongqing 400016,China)

机构地区：[1]重庆医科大学附属第一医院传染病寄生虫病研究所寄生虫病研究室,重庆400016

出　　处：《国际生物制品学杂志》2024年第3期175-180,共6页International Journal of Biologicals

基　　金：国家自然科学基金(No.30801052, 30671835, 30500423, 30200239)。

摘　　要：狂犬病病毒(rabies virus, RABV)感染导致的狂犬病是人兽共患的中枢神经系统急性传染病, 而接种疫苗是防治狂犬病的主要方式。RABV糖蛋白和核蛋白是2种有效的候选疫苗抗原, 但其蛋白疫苗或核酸疫苗仍存在一些缺陷, 有必要探索载体介导的RABV疫苗。此文概述了腺病毒、痘病毒、α病毒、疱疹病毒、植物乳杆菌和根癌农杆菌等载体介导的RABV蛋白疫苗的构建及其免疫机制等方面的研究现状。Rabies caused by rabies virus(RABV)is an acute infectious zoonosis of central nervous system,and vaccination is the main way to prevent and treat rabies.The RABV glycoprotein and nucleoprotein are 2 types of effective candidate molecules of vaccine,but its protein and nucleic acid vaccines have some shortcomings,so vector-mediated RABV vaccines need to be explored.This paper reviews the research status of the construction and immune mechanism of RABV protein vaccine mediated by adenovirus,poxvirus,alphavirus,herpesvirus,Lactobacillus plantarum and A.tumefaciens.

关 键 词：狂犬病病毒 糖蛋白 核蛋白 疫苗 

分 类 号：S852.65[农业科学—基础兽医学]