Highly selectiveα-C(sp^(3))-H arylation of alkenyl amides via nickel chain-walking catalysis  

作　　者：Haoran Shi Jiaxin Wang Yuqin Zhu Hongyang Li Guodong Ju Lanlan Zhang Chao Wang 

机构地区：[1]Tianjin Key Laboratory of Structure and Performance for Functional Molecules,College of Chemistry,Tianjin Normal University,Tianjin 300387,China

出　　处：《Chinese Chemical Letters》2024年第7期271-275,共5页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.21901185 and 22301216);funds provided by Tianjin Normal University。

摘　　要：Herein,we report the migratory hydroarylation of unactivated alkenes with aryl iodides using native and weakly coordinating amide directors under mild conditions.Synergistic coordination of the monodentate directing group and the ligand enable the highly regioselective migratory hydroarylation via a chain walking process to form the thermodynamically stable five-membered nickelacyle intermediate.The protocol provides a variety of valuableα-aryl-substituted alkylamine products,and exhibited good functional group tolerance.The modification of bioactive compounds such as fenofibrate and indomethacin further highlights the synthetic value of this protocol.

关 键 词：Alkenes HYDROARYLATION Chain-walking Regioselective Nickel catalysis 

分 类 号：O621.251[理学—有机化学]