Nano metal-photosensitizer based on Aza-BODIPY-Cu complex for CDT-enhanced dual phototherapy  

作　　者：Wenjuan Jin Zelong Chen Yi Wang Jiaxuan Li Jiahui Li Yuxin Pei Zhichao Pei 

机构地区：[1]College of Chemistry&Pharmacy,Northwest A&F University,Yangling 712100,China

出　　处：《Chinese Chemical Letters》2024年第7期296-300,共5页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.22171230);the Project of Science and Technology of Social Development in Shaanxi Province(No.2023YBSF-151)。

摘　　要：Chemodynamic therapy(CDT)combined with dual phototherapy(photothermal therapy(PTT)and photodynamic therapy(PDT))is an efficient way to synergistically improve anti-tumor efficacy.However,the combination of multiple modes often makes the composition of the system more complex,which is not conducive to clinical application.In this study,a dual phototherapy ligand carboxyl-modified Aza-BODIPY(BOD-COOH)and metal active center Cu^(2+)were used to construct multiple-modes metalphotosensitizer nanoparticles(BOD-Cu NPs)via one-step coordination self-assembly for combination therapy of CDT/PDT/PTT.In order to improve delivery efficiency,the targeted hydrophilic molecule pyridinemodified glucose derivative(G-Py)was synthesized and coated onto the BOD-Cu NPs to form a glycosylated nano metal-photosensitizer BOD-Cu@G by electrostatic interaction.The Cu^(2+)in BOD-Cu@G could not only be used as a coordination node for metal-driven self-assembly but also consume intracellular glutathione(GSH),and then catalyze Fenton-like reaction to generate hydroxyl radical(·OH)for CDT.In vitro and in vivo studies revealed that BOD-Cu@G could achieve excellent anti-tumor efficiency by CDTenhanced dual phototherapy.

关 键 词：Nano metal-photosensitizer Aza-BODIPY-Cu Coordination self-assembly Chemodynamic therapy Dual phototherapy 

分 类 号：TQ421.7[化学工程] TB383.1[一般工业技术—材料科学与工程] R730.5[医药卫生—肿瘤]