T细胞亚群及血清IL-6、IL-17水平对类风湿关节炎预后的评价  

Evaluation of T-cell subsets and serum IL-6,IL-17 levels on the prognosis of rheumatoid arthritis

作　　者：叶敏[1] YE Min(Department of Clinical Laboratory,Deyang People's Hospital,Deyang 618000,China.)

机构地区：[1]德阳市人民医院检验科,四川德阳618000

出　　处：《医师在线》2024年第7期16-19,共4页Journal of Doctors Online

摘　　要：目的分析T细胞亚群及血清白细胞介素(IL)-6、IL-17水平对类风湿关节炎(RA)预后的影响。方法选取2021年9月~2023年9月收治的102例RA患者为研究对象,均接受甲氨蝶呤片治疗3个月,于治疗前、治疗后采集患者空腹血液标本,使用流式细胞仪测定T细胞亚群(CD4^(+)、CD8^(+))水平,使用酶联免疫吸附法(ELISA)测定血清IL-6、IL-17水平。统计所有患者临床预后情况,比较不同预后患者T细胞亚群及血清IL-6、IL-17水平。结果RA患者重度活动组的CD4^(+)/CD8^(+)、血清IL-6、IL-17水平均高于中度及轻度活动组(P<0.05)。RA患者治疗后CD4^(+)、血清IL-6、IL-17水平较治疗前降低,CD8^(+)较治疗前升高(P<0.05)。102例RA患者中,72例预后良好,占比70.59%,30例为预后不良,占比29.41%。预后不良的RA患者治疗后CD4^(+)、血清IL-6、IL-17水平较预后良好者高,CD8^(+)较预后良好者低(P<0.05)。结论CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)、血清IL-6、IL-17水平与RA患者预后情况显著相关。Objective To analyze the effects of T-cell subsets,serum interleukin(IL)-6 and IL-17 levels on the prognosis of rheumatoid arthritis(RA).Methods A total of 102 RA patients admitted from September 2021 to September 2023 were selected as the study subjects.All patients were treated with methotrexate tablets for 3 months.Fasting blood specimens were collected from the patients before and after treatment.The levels of T-cell subsets(CD4^(+),CD8^(+))were determined using flow cytometry,and the levels of serum IL-6 and IL-17 were determined using enzyme-linked immunosorbent assay(ELISA).The clinical prognosis of all patients was statistically analyzed,and the T-cell subsets and serum IL-6 and IL-17 levels of patients with different prognoses were compared.Results The levels of CD4^(+)/CD8^(+),serum IL-6 and IL-17 in severe active group of RA patients were higher than those in moderate and mild active groups(P<0.05).CD4^(+),serum IL-6,IL-17 levels were lower and CD8^(+)was higher in RA patients after treatment than those before treatment(P<0.05).Among the 102 RA patients,72 cases had a good prognosis,accounting for 70.59%,and 30 cases had a poor prognosis,accounting for 29.41%.CD4^(+),serum IL-6 and IL-17 levels after treatment were higher in poor prognosis RA patients than those in good prognosis ones,and CD8^(+)was lower than that in good prognosis ones(P<0.05).Conclusion CD4^(+),CD8^(+),CD4^(+)/CD8^(+),serum IL-6 and IL-17 levels are strongly associated with the prognosis of RA patients.

关 键 词：T细胞亚群 IL-6 IL-17 类风湿关节炎 

分 类 号：R73[医药卫生—肿瘤]